Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30567099 | 1.00 | DHFR (0.49) | DHFRMEN1KMT2AMAPTNPSR1 | |
| Hydrochloric Acid SCHEMBL3861907 | 0.98 | DHFR (0.47) | DHFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL30548760 | 0.84 | HTR1A (0.51) | DHFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL3095695 | 0.83 | CYP3A4 (0.56) | DHFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL11546 | 0.82 | MAPT (0.56) | DHFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL29613097 | 0.82 | MAPT (0.56) | DHFRMEN1KMT2AMAPTNPSR1 | |
| Hydrochloric Acid SCHEMBL5211034 | 0.80 | MAPT (0.54) | DHFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL546833 | 0.79 | DHFR (0.49) | DHFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL1713296 | 0.79 | CYP1A2 (0.53) | DHFRMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL31016398 | 0.79 | CYP1A2 (0.53) | DHFRMEN1KMT2AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102131791-B | Dibenzothiepiazane derivatives and their use | ASTRAZENECA SWEDEN AB | 2014-12-24 | — | — | CN | claimed |
| CN-102131791-B | Dibenzothiepiazane derivatives and their use | ASTRAZENECA SWEDEN AB | 2014-12-24 | — | — | CN | disclosed |
| US-8653257-B2 | Dibenzothiazepine derivatives and uses thereof—424 | ASTRAZENECA AB (SE) | 2014-02-18 | — | — | US | disclosed |
| US-8653257-B2 | Dibenzothiazepine derivatives and uses thereof—424 | ASTRAZENECA AB (SE) | 2014-02-18 | — | — | US | disclosed |
| EP-2307389-B1 | DIBENZOTHIAZEPINE DERIVATIVE AND USE THEREOF | ASTRAZENECA AB (SE) | 2013-01-23 | — | — | EP | disclosed |
| US-20120202991-A1 | DIBENZOTHIAZEPINE DERIVATIVES AND USES THEREOF - 424 | ASTRAZENECA AB (SE) | 2012-08-09 | — | — | US | disclosed |
| US-20120202991-A1 | DIBENZOTHIAZEPINE DERIVATIVES AND USES THEREOF - 424 | ASTRAZENECA AB (SE) | 2012-08-09 | — | — | US | disclosed |
| US-8158618-B2 | Dibenzothiazepine derivatives and uses thereof—424 | ASTRAZENECA AB (SE) | 2012-04-17 | — | — | US | disclosed |
| US-8158618-B2 | Dibenzothiazepine derivatives and uses thereof—424 | ASTRAZENECA AB (SE) | 2012-04-17 | — | — | US | disclosed |
| CN-102131791-A | Dibenzothiepiazane derivatives and their use | ASTRAZENECA AB | 2011-07-20 | — | — | CN | disclosed |
| US-20110160184-A1 | Dibenzothiazepine Derivatives and Use Thereof | ASTRAZENECA AB (SE) | 2011-06-30 | — | — | US | disclosed |
| US-20110160184-A1 | Dibenzothiazepine Derivatives and Use Thereof | ASTRAZENECA AB (SE) | 2011-06-30 | — | — | US | disclosed |
| US-20090318415-A1 | DIBENZOTHIAZEPINE DERIVATIVES AND USES THEREOF - 424 | ASTRAZENECA AB (SE) | 2009-12-24 | — | — | US | disclosed |
| US-20090318415-A1 | DIBENZOTHIAZEPINE DERIVATIVES AND USES THEREOF - 424 | ASTRAZENECA AB (SE) | 2009-12-24 | — | — | US | disclosed |
| WO-2009154563-A1 | DIBENZOTHIAZEPINE DERIVATIVES AND USE THEREOF | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | WO | disclosed |
| US-7592454-B2 | Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-22 | — | — | US | disclosed |
| US-20050239768-A1 | Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318415-A1 | DIBENZOTHIAZEPINE DERIVATIVES AND USES THEREOF - 424 | DRD4, DRD2, GABBR1 | DHFR 1541/4885MEN1 2691/4885KMT2A 743/4885 |
| US-20110160184-A1 | Dibenzothiazepine Derivatives and Use Thereof | DRD2, DRD4, GABBR1 | DHFR 1426/4885MEN1 2365/4885KMT2A 814/4885 |
| US-20050239768-A1 | Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists | HTR1A, HTR7, HTR1D | DHFR 451/4885MEN1 1784/4885KMT2A 3004/4885 |
| US-20120202991-A1 | DIBENZOTHIAZEPINE DERIVATIVES AND USES THEREOF - 424 | DRD4, DRD2, GABBR1 | DHFR 1541/4885MEN1 2691/4885KMT2A 743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.