Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 17/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21392831 | 0.84 | KDM4E (0.70) | KDM4EATMALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL4733402 | 0.75 | ALDH1A1 (0.59) | KDM4EATMALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL28549394 | 0.72 | CFTR (0.56) | KDM4EATMALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4732816 | 0.72 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10HPGDKMT2A | |
| SCHEMBL4736645 | 0.71 | HPGD (0.68) | KDM4EATMALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL23044925 | 0.71 | ALDH1A1 (0.46) | KDM4EATMALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL24131819 | 0.70 | NR4A2 (0.48) | KDM4EATMALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL3267660 | 0.70 | PTPRC (0.44) | KDM4EATMALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL9100705 | 0.70 | KDM4E (0.77) | KDM4EATMALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL7897290 | 0.70 | KDM4E (0.77) | KDM4EATMALDH1A1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230271932-A1 | SMALL MOLECULE COVALENT ACTIVATORS OF UCP1 | DANA FARBER CANCER INST INC (US) | 2023-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271932-A1 | SMALL MOLECULE COVALENT ACTIVATORS OF UCP1 | PC, FABP4, PCK2 | KDM4E 2940/4885ATM 3001/4885ALDH1A1 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.