Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.64 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.64 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.64 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2619124 | 0.85 | MAPKAPK2 (0.50) | RPS6KA3MAPKAPK2CSNK2A1PLK3ALDH1A1 | |
| SCHEMBL19519842 | 0.78 | MAPKAPK2 (0.64) | RPS6KA3MAPKAPK2CSNK2A1PLK3ALDH1A1 | |
| SCHEMBL706811 | 0.78 | MAPKAPK2 (0.64) | RPS6KA3MAPKAPK2CSNK2A1PLK3ALDH1A1 | |
| SCHEMBL7757513 | 0.78 | RPS6KA3 (0.64) | RPS6KA3MAPKAPK2CSNK2A1PLK3ALDH1A1 | |
| SCHEMBL782851 | 0.78 | RPS6KA3 (0.64) | RPS6KA3MAPKAPK2CSNK2A1PLK3ALDH1A1 | |
| SCHEMBL558709 | 0.77 | MAPKAPK2 (0.58) | RPS6KA3MAPKAPK2CSNK2A1PLK3ALDH1A1 | |
| SCHEMBL19300290 | 0.77 | MAPKAPK2 (0.58) | RPS6KA3MAPKAPK2CSNK2A1PLK3ALDH1A1 | |
| SCHEMBL2611068 | 0.77 | MAPKAPK2 (0.58) | RPS6KA3MAPKAPK2CSNK2A1PLK3ALDH1A1 | |
| SCHEMBL2948093 | 0.77 | MAPKAPK2 (0.53) | RPS6KA3MAPKAPK2CSNK2A1PLK3ALDH1A1 | |
| SCHEMBL24427810 | 0.76 | MAPKAPK2 (0.53) | RPS6KA3MAPKAPK2CSNK2A1PLK3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119684221-A | Synthesis method and application of C-3-hydroxyfluoroalkyl substituted quinoxalinone derivative | 天津科技大学 | 2025-03-25 | — | — | CN | disclosed |
| US-20230159446-A1 | Methods and Compositions for Targeting Tregs using CCR8 Inhibitors | NANJING IMMUNOPHAGE BIOMEDICAL CO., LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
| CN-113603651-B | Method for preparing 3-sulfur substituted quinoxalinone derivatives by catalysis | 浙江树人学院（浙江树人大学） | 2022-12-13 | — | — | CN | disclosed |
| US-11518766-B2 | Tricyclic compound, preparation method therefor and use thereof | SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD. (CN) | 2022-12-06 | — | — | US | disclosed |
| EP-3998263-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Jemincare Pharmaceuticals Co., Ltd. (CN) | 2022-05-18 | — | — | EP | disclosed |
| CN-113603651-A | Method for preparing 3-sulfur substituted quinoxalinone derivatives by catalysis | 浙江树人学院（浙江树人大学） | 2021-11-05 | — | — | CN | disclosed |
| US-20170247326-A1 | Substituted Pyrrolidine Carboxamide Compounds | Epizyme, Inc. (US) | 2017-08-31 | — | — | US | disclosed |
| EP-2046799-B1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH INC (US) | 2017-07-19 | — | — | EP | disclosed |
| EP-2526102-B1 | Inhibitors of PI3 kinase | FUNDACIÓN CENTRO NAC DE INVESTIG ONCOLÓGICAS CARLOS III (ES) | 2017-03-08 | — | — | EP | disclosed |
| EP-2760856-B1 | SELECTIVE NR2B ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2016-09-14 | — | — | EP | disclosed |
| US-20090137597-A1 | Novel quinoxalinone derivatives | MSD K.K. (JP) | 2009-05-28 | — | — | US | disclosed |
| US-20090118275-A1 | THIAZOLOPYRIMIDINE P13K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-05-07 | — | — | US | disclosed |
| US-20080039459-A1 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | PLRAMED LIMITED (GB) | 2008-02-14 | — | — | US | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |
| WO-2007087250-A2 | TRICYCLIC INHIBITORS OF 5-LIPOXYGENASE | AMIRA PHARMACEUTICALS, INC. (US) | 2007-08-02 | — | — | WO | disclosed |
| US-20070173508-A1 | TRICYCLIC INHIBITORS OF 5-LIPOXYGENASE | AMIRA PHARMACEUTICALS, INC. (US) | 2007-07-26 | — | — | US | disclosed |
| US-20070173508-A1 | TRICYCLIC INHIBITORS OF 5-LIPOXYGENASE | AMIRA PHARMACEUTICALS, INC. (US) | 2007-07-26 | — | — | US | disclosed |
| EP-0339411-B1 | PROCESS FOR THE PREPARATION OF QUINOXALONES | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-08-12 | — | — | EP | disclosed |
| EP-0339411-A1 | Process for the preparation of quinoxalones | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-02 | — | — | EP | disclosed |
| EP-0000346-B1 | QUINOXALINE COMPOUNDS, PROCESS FOR THEIR MANUFACTURE AND THEIR USE AS BRIGHTENERS FOR ORGANIC MATERIALS, AND THE MATERIALS BRIGHTENED THEREWITH | BAYER AG (DE) | 1980-01-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159446-A1 | Methods and Compositions for Targeting Tregs using CCR8 Inhibitors | CCR8, CCR1, CCR3 | RPS6KA3 2635/4885MAPKAPK2 2873/4885CSNK2A1 2696/4885 |
| US-20070173508-A1 | TRICYCLIC INHIBITORS OF 5-LIPOXYGENASE | ALOX5, ALOX15, ALOX15B | RPS6KA3 3784/4885MAPKAPK2 3569/4885CSNK2A1 4653/4885 |
| US-20080039459-A1 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | PIK3CA, PI4KB, PI4KA | RPS6KA3 228/4885MAPKAPK2 89/4885CSNK2A1 332/4885 |
| US-20090118275-A1 | THIAZOLOPYRIMIDINE P13K INHIBITOR COMPOUNDS AND METHODS OF USE | PIK3CA, PI4KB, PI4KA | RPS6KA3 198/4885MAPKAPK2 117/4885CSNK2A1 395/4885 |
| US-20090137597-A1 | Novel quinoxalinone derivatives | NDUFB1, NDUFB6, NDUFB7 | RPS6KA3 3266/4885MAPKAPK2 2948/4885CSNK2A1 1176/4885 |
| US-11518766-B2 | Tricyclic compound, preparation method therefor and use thereof | TFPI, TFPI2, F11 | RPS6KA3 3816/4885MAPKAPK2 1150/4885CSNK2A1 1147/4885 |
| US-20170247326-A1 | Substituted Pyrrolidine Carboxamide Compounds | SMYD3, SMYD2, SMURF2 | RPS6KA3 944/4885MAPKAPK2 2261/4885CSNK2A1 1287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.