Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 13/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL262351 | 0.91 | CHKA (0.48) | CHKABCHEACHE | |
| Hydrochloric Acid SCHEMBL262371 | 0.88 | CHKA (0.56) | CHKABCHEACHE | |
| SCHEMBL9834829 | 0.76 | USP2 (0.44) | CHKABCHEACHESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9674296 | 0.75 | USP2 (0.43) | CHKABCHEACHESMN1; SMN2 | |
| SCHEMBL9329679 | 0.71 | CHKA (0.62) | CHKABCHEACHE | |
| Bromide SCHEMBL9327388 | 0.70 | CHKA (0.66) | CHKABCHEACHE | |
| SCHEMBL560191 | 0.69 | PTGS2 (0.43) | CHKABCHEACHESMN1; SMN2 | |
| SCHEMBL560190 | 0.69 | PTGS2 (0.43) | CHKABCHEACHESMN1; SMN2 | |
| SCHEMBL9328178 | 0.69 | CHKA (0.61) | CHKABCHEACHE | |
| SCHEMBL2314961 | 0.69 | PTGS2 (0.42) | CHKABCHEACHESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060205958-A1 | Direct dianhydride synthesis | GENERAL ELECTRIC COMPANY | 2006-09-14 | — | — | US | claimed |
| EP-2280963-B1 | METHOD OF PURIFYING DIANHYDRIDES, THE DIANHYDRIDES FORMED THEREBY, AND POLYETHERIMIDES FORMED THEREFROM | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2016-07-20 | — | — | EP | disclosed |
| EP-2097375-B1 | METHOD FOR PURIFYING BISIMIDES | SABIC INNOVATIVE PLASTICS IP (NL) | 2013-04-24 | — | — | EP | disclosed |
| EP-2089348-B1 | METHOD FOR MAKING POLYETHERIMIDES | SABIC INNOVATIVE PLASTICS IP (NL) | 2013-02-20 | — | — | EP | disclosed |
| US-8134016-B2 | Method for purifying dianhydrides | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2012-03-13 | — | — | US | disclosed |
| US-8013173-B2 | Method of purifying dianhydrides, the dianhydrides formed thereby, and polyetherimides formed therefrom | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2011-09-06 | — | — | US | disclosed |
| EP-2094691-B1 | METHOD FOR PURIFYING DIANHYDRIDES | SABIC INNOVATIVE PLASTICS IP (NL) | 2011-05-25 | — | — | EP | disclosed |
| EP-2280963-A1 | METHOD OF PURIFYING DIANHYDRIDES, THE DIANHYDRIDES FORMED THEREBY, AND POLYETHERIMIDES FORMED THEREFROM | SABIC Innovative Plastics IP B.V. (NL) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009120212-A1 | METHOD OF PURIFYING DIANHYDRIDES, THE DIANHYDRIDES FORMED THEREBY, AND POLYETHERIMIDES FORMED THEREFROM | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2009-10-01 | — | — | WO | disclosed |
| US-20090247727-A1 | Method of Purifying Dianhydrides, the Dianhydrides Formed Thereby, and Polyetherimides Formed Therefrom | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2009-10-01 | — | — | US | disclosed |
| WO-2008082417-A1 | METHOD OF PURIFYING DIANHYDRIDES | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2008-07-10 | — | — | WO | disclosed |
| WO-2008063208-A1 | METHOD FOR PURIFYING BISIMIDES | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008063206-A1 | METHOD FOR MAKING POLYETHERIMIDES | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008063207-A1 | METHOD FOR PURIFYING DIANHYDRIDES | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2008-05-29 | — | — | WO | disclosed |
| US-7268237-B2 | Direct dianhydride synthesis | GENERAL ELECTRIC COMPANY (US) | 2007-09-11 | — | — | US | disclosed |
| US-20070073066-A1 | Method for purifying dianhydrides | GENERAL ELECTRIC COMPANY (US) | 2007-03-29 | — | — | US | disclosed |
| US-20070073035-A1 | Method for making polyetherimides | GENERAL ELECTRIC COMPANY (US) | 2007-03-29 | — | — | US | disclosed |
| US-20070073063-A1 | Method for purifying bisimides | GENERAL ELECTRIC COMPANY (US) | 2007-03-29 | — | — | US | disclosed |
| US-20060293528-A1 | Method of purifying dianhydrides | GENERAL ELECTRIC COMPANY | 2006-12-28 | — | — | US | disclosed |
| US-20060205958-A1 | Direct dianhydride synthesis | GENERAL ELECTRIC COMPANY | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205958-A1 | Direct dianhydride synthesis | HDHD5, DOHH, DBH | CHKA 3705/4885BCHE 683/4885ACHE 1387/4885 |
| US-20070073063-A1 | Method for purifying bisimides | FHIT, PBRM1, TNS4 | CHKA 4501/4885BCHE 1284/4885ACHE 3216/4885 |
| US-20060293528-A1 | Method of purifying dianhydrides | CA3, UROD, CA7 | CHKA 4432/4885BCHE 959/4885ACHE 2507/4885 |
| US-20070073066-A1 | Method for purifying dianhydrides | AQP4, TRRAP, GYPA | CHKA 4567/4885BCHE 2510/4885ACHE 3414/4885 |
| US-20090247727-A1 | Method of Purifying Dianhydrides, the Dianhydrides Formed Thereby, and Polyetherimides Formed Therefrom | CA7, CA4, CA13 | CHKA 4367/4885BCHE 3069/4885ACHE 3011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.