Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20564582 | 0.87 | TP53 (0.41) | TP53THRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26324999 | 0.84 | ALOX5 (0.37) | RAB9ATDP1ALDH1A1LMNAKMT2A | |
| SCHEMBL26324940 | 0.81 | TRPM8 (0.39) | NPC1RAB9ASMN1; SMN2TRPM8TDP1 | |
| SCHEMBL26324989 | 0.80 | HPGD (0.42) | TP53NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL26324953 | 0.77 | HSD17B1 (0.40) | TP53NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL26324966 | 0.75 | TP53 (0.37) | TP53THRBRAB9ASMN1; SMN2TDP1 | |
| SCHEMBL26324996 | 0.75 | ALDH1A1 (0.37) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL26324800 | 0.73 | TSHR (0.42) | TP53NPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL26327837 | 0.72 | TP53 (0.43) | TP53THRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25439936 | 0.72 | ALOX5 (0.42) | RAB9ATDP1ALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767291-B2 | Preparation of secondary amines with electrophilic N-linchpin reagents | WILLIAM MARSH RICE UNIVERSITY (US) | 2023-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11767291-B2 | Preparation of secondary amines with electrophilic N-linchpin reagents | PNMT, NCL, NPM1 | TP53 2601/4885THRB 3828/4885NPC1 2535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.