Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 7/20 | 0.45 |
| ▸ | RXRA | P19793 | 3/20 | 0.45 |
| ▸ | RXRB | P28702 | 3/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30559643 | 0.83 | KMO (0.56) | LOXL2KMORXRARXRBRAB9A | |
| SCHEMBL8255870 | 0.80 | ASIC3 (0.53) | KMORAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL16380507 | 0.79 | LOXL2 (0.49) | LOXL2KMORXRARXRBRAB9A | |
| SCHEMBL12891149 | 0.77 | CYP1A2 (0.44) | EGFRTP53CYP1A2CYP2C9CLK4 | |
| SCHEMBL14063538 | 0.76 | RXRA (0.54) | LOXL2RXRARXRBRXRGKDM4E | |
| SCHEMBL25754733 | 0.74 | FAAH (0.46) | RAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL2627853 | 0.73 | TARS1 (0.36) | KMORAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL22645101 | 0.73 | KMT2A (0.38) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL4900073 | 0.73 | KMO (0.69) | KMORXRARXRBCYP1A2KDM4E | |
| SCHEMBL19919584 | 0.71 | KMO (0.46) | KMOKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095001-A1 | SUBSTITUTED-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONES | MERCK SHARP & DOHME CORP. (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095001-A1 | SUBSTITUTED-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONES | HIF1AN, HIF1A, EGLN2 | LOXL2 2794/4885KMO 1662/4885RXRA 1621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.