SCHEMBL263329

SCHEMBL263329

NCCCCCNc1c(S(=O)(=O)O)cc2c3c(cc(S(=O)(=O)O)cc13)C(=O)NC2=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRKD3 O94806 3/20 0.33
▸ PRKCG P05129 3/20 0.33
▸ PRKCB P05771 3/20 0.33
▸ PRKCA P17252 3/20 0.33
▸ PRKCH P24723 3/20 0.33
▸ PRKCI P41743 3/20 0.33
▸ PRKCE Q02156 3/20 0.33
▸ PRKCQ Q04759 3/20 0.33
▸ PRKCZ Q05513 3/20 0.33
▸ PRKCD Q05655 3/20 0.33
▸ PRKD1 Q15139 3/20 0.33
▸ PRKACA P17612 1/20 0.33
▸ PRKACG P22612 1/20 0.33
▸ PRKACB P22694 1/20 0.33
▸ MEN1 O00255 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ TP53 P04637 1/20 0.31
▸ CYP1A2 P05177 1/20 0.31
▸ CYP3A4 P08684 1/20 0.31
▸ CYP2D6 P10635 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL301992 0.92 MEN1 (0.30) MEN1ALDH1A1CYP2C9CYP2C19KMT2A
SCHEMBL19357602 0.84 PRKD3 (0.34) PRKD3PRKCGPRKCBPRKCAPRKCH
Potassium Ion SCHEMBL9152245 0.77 — —
SCHEMBL170998 0.74 ALDH1A1 (0.39) MEN1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL27426620 0.73 CASP6 (0.38) MEN1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL28120681 0.70 MEN1 (0.39) MEN1ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL2405485 0.64 MEN1 (0.49) MEN1ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL17145936 0.62 GSK3B (0.45) PRKD3PRKCGPRKCBPRKCAPRKCH
SCHEMBL9293198 0.62 CASP6 (0.47) MEN1ALDH1A1TP53CYP1A2CYP3A4
SCHEMBL21404284 0.61 CLTC (0.40) MEN1ALDH1A1CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8133411-B2 Fluorescent polymers soluble in an aqueous solution and a method for the production thereof BIOMERIEUX S.A. (FR) 2012-03-13 — — US claimed
US-20090054532-A1 Modulators of Retinol-Retinol Binding Protein (RBP)-Transthyretin (TTR) Complex Formation SIRION THERAPEUTICS, INC. (US) 2009-02-26 — — US claimed
US-20080290321-A1 Fluorescent Polymers Soluble in an Aqueous Solution and a Method for the Production Thereof BIOMERIEUX S.A. (FR) 2008-11-27 — — US claimed
EP-1899434-A1 FLUORESCENT POLYMERS SOLUBLE IN AN AQUEOUS SOLUTION AND A METHOD FOR THE PRODUCTION THEREOF bioMérieux S.A. (FR) 2008-03-19 — — EP claimed
EP-1807103-A2 MODULATORS OF RETINOL-RETINOL BINDING PROTEIN (RBP)-TRANSTHYRETIN (TTR) COMPLEX FORMATION Sirion Therapeutics, Inc. (US) 2007-07-18 — — EP claimed
WO-2007003781-A1 FLUORESCENT POLYMERS SOLUBLE IN AN AQUEOUS SOLUTION AND A METHOD FOR THE PRODUCTION THEREOF BIOMERIEUX S.A. (FR) 2007-01-11 — — WO claimed
WO-2006052860-A2 MODULATORS OF RETINOL-RETINOL BINDING PROTEIN (RBP)-TRANSTHYRETIN (TTR) COMPLEX FORMATION SIRION THERAPEUTICS, INC. (US) 2006-05-18 — — WO claimed
US-20060094063-A1 Modulators of retinol-retinol binding protein (RBP)-transthyretin (TTR) complex formation SYTERA, INC. (US) 2006-05-04 — — US claimed
WO-2024148174-A1 PEPTIDE SEQUENCER OREGON HEALTH & SCIENCE UNIVERSITY (US) 2024-07-11 — — WO disclosed
US-20220389478-A1 METHODS TO DETERMINE KDM1A TARGET ENGAGEMENT AND CHEMOPROBES USEFUL THEREFOR ORYZON GENOMICS SA (ES) 2022-12-08 — — US disclosed
US-20220120739-A1 CHIPS, DETECTORS, AND METHODS OF MAKING AND USING THE SAME SENTILUS HOLDCO, LLC 2022-04-21 — — US disclosed
US-11169150-B2 Chips, detectors, and methods of making and using the same Sentilus Holdco LLC (US) 2021-11-09 — — US disclosed
US-11130987-B2 Direct detection of RNA by surface initiated enzymatic polymerization SENTILUS HOLDCO, LLC (US) 2021-09-28 — — US disclosed
US-11034991-B2 Methods to determine KDM1A target engagement and chemoprobes useful therefor ORYZON GENOMICS S.A. (ES) 2021-06-15 — — US disclosed
WO-2007003782-A2 NOVEL FUNCTIONALISED TRANSFER AGENTS FOR CONTROLLED RADICAL POLYMERISATION RAFT, RAFT METHODS USING SAID TRANSFER AGENTS AND POLYMERS OBTAINABLE THEREBY BIOMERIEUX S.A. (FR) 2007-01-11 — — WO disclosed
WO-2007003781-A1 FLUORESCENT POLYMERS SOLUBLE IN AN AQUEOUS SOLUTION AND A METHOD FOR THE PRODUCTION THEREOF BIOMERIEUX S.A. (FR) 2007-01-11 — — WO disclosed
WO-2006052860-A2 MODULATORS OF RETINOL-RETINOL BINDING PROTEIN (RBP)-TRANSTHYRETIN (TTR) COMPLEX FORMATION SIRION THERAPEUTICS, INC. (US) 2006-05-18 — — WO disclosed
US-20060094063-A1 Modulators of retinol-retinol binding protein (RBP)-transthyretin (TTR) complex formation SYTERA, INC. (US) 2006-05-04 — — US disclosed
EP-0938675-B1 ANALYSIS OF CARBOHYDRATES AMERSHAM PLC (GB) 2003-05-07 — — EP disclosed
US-6294667-B1 SEPARATION OF THE FLUORESCENTLY LABELLED CARBOHYDRATE SUBSTANCES, BY VIRTUE OF THEIR DIFFERENT CHARGE-TO-MASS RATIOS OR OTHER FACTORS, ENABLING A LARGER NUMBER OF DIFFERENT LABELLED CARBOHYDRATE SUBSTANCES TO BE SEPARATED AMERSHAM INTERNATIONAL PLC 2001-09-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220389478-A1 METHODS TO DETERMINE KDM1A TARGET ENGAGEMENT AND CHEMOPROBES USEFUL THEREFOR KDM1B, KDM1A, KDM7A PRKD3 2164/4885PRKCG 1318/4885PRKCB 586/4885
US-20090054532-A1 Modulators of Retinol-Retinol Binding Protein (RBP)-Transthyretin (TTR) Complex Formation RBP1, TTR, RBP4 PRKD3 3548/4885PRKCG 2427/4885PRKCB 2262/4885
US-20060094063-A1 Modulators of retinol-retinol binding protein (RBP)-transthyretin (TTR) complex formation RBP1, TTR, RBP4 PRKD3 3548/4885PRKCG 2427/4885PRKCB 2262/4885
US-11034991-B2 Methods to determine KDM1A target engagement and chemoprobes useful therefor KDM1B, KDM1A, KDM7A PRKD3 2164/4885PRKCG 1318/4885PRKCB 586/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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