SCHEMBL2636747

SCHEMBL2636747

O=C(O)c1ccc(O)c([N+](=O)[O-])c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP6 P55212 1/20 0.72
TSHR P16473 3/20 0.66
LMNA P02545 1/20 0.66
HCAR3 P49019 8/20 0.60
MAPK1 P28482 2/20 0.58
ALDH1A1 P00352 1/20 0.58
TP53 P04637 1/20 0.58
HPGD P15428 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
GPR35 Q9HC97 1/20 0.58
L3MBTL1 Q9Y468 2/20 0.56
ALOX15 P16050 1/20 0.56
HSD17B10 Q99714 1/20 0.56
APEX1 P27695 1/20 0.55
KDM4E B2RXH2 1/20 0.55
CA12 O43570 1/20 0.55
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55
POLB P06746 1/20 0.55
GAA P10253 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL106249 1.00 CASP6 (0.72) CASP6TSHRLMNAHCAR3MAPK1
SCHEMBL1898142 0.98 CASP6 (0.70) CASP6TSHRLMNAHCAR3MAPK1
SCHEMBL9469176 0.98 CASP6 (0.70) CASP6TSHRLMNAHCAR3MAPK1
Hydrochloric Acid SCHEMBL10607831 0.96 CASP6 (0.68) CASP6TSHRLMNAHCAR3MAPK1
Benzoic Acid SCHEMBL28359564 0.93 CASP6 (0.64) CASP6TSHRLMNAHCAR3MAPK1
SCHEMBL7103159 0.86 VCAM1 (0.65) CASP6TSHRLMNAMAPK1ALDH1A1
SCHEMBL2156599 0.86 MAPK1 (0.60) CASP6TSHRLMNAMAPK1ALDH1A1
SCHEMBL4340852 0.86 ERN1 (0.61) CASP6TSHRLMNAMAPK1ALDH1A1
SCHEMBL9660912 0.85 GPR35 (0.55) CASP6TSHRLMNAHCAR3MAPK1
SCHEMBL459609 0.85 CASP6 (0.72) CASP6TSHRLMNAHCAR3TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 EP claimed
WO-2025090061-A1 ULTRASONIC INDICATOR DEVICE AND METHOD FOR MONITORING ULTRASONICATION JP LABORATORIES, INC. (US) 2025-05-01 WO claimed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 WO claimed
US-12630844-B2 Hepatitis E virus-like particles (VLPs) derived from consensus sequences NOVO CAPSID TECHNOLOGIES LLC (US) 2026-05-19 US disclosed
US-20250236885-A1 HEPATITIS E VIRUS-LIKE PARTICLES (VLPS) DERIVED FROM CONSENSUS SEQUENCES NOVO CAPSID TECHNOLOGIES LLC (US) 2025-07-24 US disclosed
WO-2025128404-A2 HEPATITIS E VIRUS-LIKE PARTICLES (VLPS) DERIVED FROM CONSENSUS SEQUENCES NOVO CAPSID TECHNOLOGIES LLC (US) 2025-06-19 WO disclosed
CN-119780316-A Separation method for overcoming plastic interference in soil-soluble organic matter extraction process 南京师范大学 2025-04-08 CN disclosed
CN-109503518-B Substituted biaryl amide compound and preparation method and application thereof 中国医学科学院医药生物技术研究所 2021-03-30 CN disclosed
CN-109503518-A A kind of substituted double aromatic radical amide compounds and its preparation method and application 中国医学科学院医药生物技术研究所 2019-03-22 CN disclosed
CN-103113321-B 2- (methylthio) benzo [ d ] oxazole-5-carboxylic acid and preparation method thereof UNIV NANTONG 2015-02-18 CN disclosed
CN-103113321-A 2- (methylthio) benzo [ d ] oxazole-5-carboxylic acid and preparation method thereof UNIV NANTONG 2013-05-22 CN disclosed
WO-2005047901-A2 COMPOSITIONS AND METHODS FOR DETECTION AND ISOLATION PHOSPHORYLATED MOLECULES MOLECULAR PROBES, INC. (US) 2005-05-26 WO disclosed
US-20050014197-A1 Compositions and methods for detection and isolation of phosphorylated molecules MOLECULAR PROBES, INC. 2005-01-20 US disclosed
US-20040171034-A1 Compositions and methods for detection and isolation of phosphorylated molecules MOLECULAR PROBES, INC. 2004-09-02 US disclosed
WO-2004042347-A2 COMPOSITIONS AND METHODS FOR DETECTION AND ISOLATION OF PHOSPHORYLATED MOLECULES MOLECULAR PROBES, INC. (US) 2004-05-21 WO disclosed
US-20040038306-A1 Compositions and methods for detection and isolation of phosphorylated molecules MOLECULAR PROBES, INC. 2004-02-26 US disclosed
EP-0882033-B1 BENZOFURAN-ACRYLIC ACID DERIVATIVES AND THEIR USE AS MODULATORS OF RXRS OR RARS RECEPTORS CT INTERNAT DE RECH S (FR) 2001-08-16 EP disclosed
EP-0882033-A1 BENZOFURAN-ACRYLIC ACID DERIVATIVES AND THEIR USE AS MODULATORS OF RXRS OR RARS RECEPTORS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) 1998-12-09 EP disclosed
US-5830999-A CARBOXYLIC LIGANDS, HEXAMERS REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-11-03 US disclosed
WO-1998024778-A1 BENZOFURAN-ACRYLIC ACID DERIVATIVES AND THEIR USE AS MODULATORS OF RXRS OR RARS RECEPTORS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) 1998-06-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630844-B2 Hepatitis E virus-like particles (VLPs) derived from consensus sequences HAVCR2, SSU72, CD74 CASP6 4045/4885TSHR 1289/4885LMNA 797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.