Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.42 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637786 | 0.83 | YTHDF2 (0.37) | ALDH1A1KDM4AKDM5AKDM4CKDM5B | |
| SCHEMBL2637806 | 0.80 | SLC22A12 (0.40) | KDM4AKDM5AKDM4CKDM5BKCNK3 | |
| SCHEMBL2637343 | 0.78 | ALDH1A1 (0.46) | ALDH1A1TDP2CASP6NPC1RAB9A | |
| SCHEMBL2637462 | 0.76 | SLC22A12 (0.41) | CCNA2CDK2CCNA1NPC1RAB9A | |
| SCHEMBL2637740 | 0.74 | KDM5A (0.41) | ALDH1A1KDM5AKDM4CKDM5BNPC1 | |
| SCHEMBL2637556 | 0.74 | POLB (0.46) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2637478 | 0.72 | HSP90AA1 (0.47) | ALDH1A1KDM4AKDM5AKDM4CKDM5B | |
| SCHEMBL3405825 | 0.71 | MAPT (0.55) | ALDH1A1NPC1TP53RAB9AMEN1 | |
| SCHEMBL3407406 | 0.70 | BRD4 (0.46) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2637759 | 0.65 | STAT1 (0.47) | CCNA2CDK2CCNA1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |