Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 6/20 | 0.35 |
| ▸ | JAK1 | P23458 | 6/20 | 0.35 |
| ▸ | PARP1 | P09874 | 6/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8785433 | 0.84 | ALDH1A1 (0.38) | ACACB | |
| SCHEMBL28309161 | 0.81 | JAK3 (0.41) | JAK2JAK1PARP1JAK3 | |
| SCHEMBL22990332 | 0.76 | ACACB (0.30) | ACACB | |
| SCHEMBL4372547 | 0.76 | BCAT2 (0.49) | JAK2JAK1PARP1PARP2 | |
| SCHEMBL26420237 | 0.76 | AR (0.36) | JAK2JAK1PARP1 | |
| SCHEMBL29002489 | 0.75 | ADORA2A (0.42) | ADORA2AADORA1PARP1PARP2PARP3 | |
| SCHEMBL31253880 | 0.75 | ROCK2 (0.36) | JAK2JAK1ROCK2 | |
| SCHEMBL30621006 | 0.74 | TGFBR1 (0.36) | JAK2JAK1PARP1PARP2PARP3 | |
| SCHEMBL21643041 | 0.73 | GRIA4 (0.40) | — | |
| SCHEMBL21643040 | 0.73 | GRIA4 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192901-A9 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023192901-A1 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |