Sugi Predict

Sugi Predict / Compounds / SCHEMBL2642790

SCHEMBL2642790

SCHEMBL2642790

Nc1nc2nccnc2s1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 3/20 0.39
▸ NOS1 P29475 3/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ ADORA2A P29274 1/20 0.35
▸ TGFBR1 P36897 1/20 0.31
▸ PIK3CD O00329 2/20 0.31
▸ PI4KA P42356 2/20 0.31
▸ PIK3CG P48736 2/20 0.31
▸ PI4KB Q9UBF8 2/20 0.31
▸ PIK3CA P42336 1/20 0.31
▸ PIK3CB P42338 1/20 0.31
▸ PIP5K1C O60331 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ GAA P10253 1/20 0.30
▸ MAPT P10636 1/20 0.30
▸ MAPK1 P28482 1/20 0.30
▸ CXCR2 P25025 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL31194791 0.98 NOS1 (0.37) HSD17B10NOS1ALDH1A1TSHRADORA2A
SCHEMBL18100112 0.73 ADORA2A (0.31) ADORA2A
SCHEMBL814058 0.71 HSD17B10 (0.33) HSD17B10ALDH1A1HPGDGAAMAPT
SCHEMBL744387 0.71 AURKA (0.32) —
SCHEMBL2668073 0.71 HPGD (0.32) HSD17B10HPGD
SCHEMBL16705689 0.71 IDO1 (0.37) ALDH1A1ADORA2AHPGDGAAMAPT
SCHEMBL6003749 0.71 NOS1 (0.38) HSD17B10NOS1ALDH1A1TSHRHPGD
SCHEMBL1862354 0.70 HSD17B10 (0.45) HSD17B10NOS1ALDH1A1TSHRPIK3CD
SCHEMBL31318718 0.70 HSD17B10 (0.41) HSD17B10NOS1ALDH1A1TSHRPIK3CD
SCHEMBL558626 0.70 HSD17B10 (0.41) HSD17B10NOS1ALDH1A1TSHRPIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3814345-B1 HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2024-09-25 — — EP claimed
WO-2025016391-A1 THIAZOLE PYRAZINE COMPOUNDS AND USE THEREOF 南京再明医药有限公司 2025-01-23 — — WO disclosed
US-20240409533-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2024-12-12 — — US disclosed
US-12139499-B2 Heteroaryl compounds for treating Huntington's disease PTC THERAPEUTICS, INC. (US) 2024-11-12 — — US disclosed
CN-113874074-B HMOX1 inducers 米托布里奇公司 2024-11-01 — — CN disclosed
US-12071433-B2 HMOX1 inducers Astellas Engineered Small Molecules US, Incorporated (US) 2024-08-27 — — US disclosed
US-20240051952-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2024-02-15 — — US disclosed
US-20220177460-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2022-06-09 — — US disclosed
US-20220177460-A1 HMOX1 INDUCERS Astellas Engineered Small Molecules US, Incorporated 2022-06-09 — — US disclosed
EP-3952990-A1 HMOX1 INDUCERS Mitobridge, Inc. (US) 2022-02-16 — — EP disclosed
US-7514439-B2 Oxime derivative and preparations thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2009-04-07 — — US disclosed
US-7514439-B2 Oxime derivative and preparations thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2009-04-07 — — US disclosed
US-20080132479-A1 Oxime Derivative and Preparations Thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-06-05 — — US disclosed
US-20080132479-A1 Oxime Derivative and Preparations Thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-06-05 — — US disclosed
WO-2007117381-A9 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS ARRAY BIOPHARMA INC (US) 2008-03-27 — — WO disclosed
US-20080032996-A1 Substituted Quinazoline or Pyridopyrimidine Derivative MSD K.K. (JP) 2008-02-07 — — US disclosed
WO-2007117381-A2 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS ARRAY BIOPHARMA INC. (US) 2007-10-18 — — WO disclosed
WO-2007089512-A1 GLUCOKINASE ACTIVATORS ARRAY BIOPHARMA INC. (US) 2007-08-09 — — WO disclosed
WO-2007007886-A1 AN OXIME DERIVATIVE AND PREPARATIONS THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2007-01-18 — — WO disclosed
EP-1734040-A1 SUBSTITUTED QUINAZOLINE OR PYRIDOPYRIMIDINE DERIVATIVE BANYU PHARMACEUTICAL CO., LTD. (JP) 2006-12-20 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12139499-B2 Heteroaryl compounds for treating Huntington's disease HTT, HYPK, HDAC6 HSD17B10 112/4885NOS1 4552/4885ALDH1A1 1911/4885
US-20080132479-A1 Oxime Derivative and Preparations Thereof GCK, KHK, GCKR HSD17B10 1208/4885NOS1 512/4885ALDH1A1 1936/4885
US-20240409533-A1 HMOX1 INDUCERS HMOX1, HMOX2, HMBS HSD17B10 278/4885NOS1 183/4885ALDH1A1 332/4885
US-12071433-B2 HMOX1 inducers HMOX1, HMOX2, HMBS HSD17B10 246/4885NOS1 94/4885ALDH1A1 223/4885
US-20240051952-A1 HMOX1 INDUCERS HMOX1, HMOX2, QSOX1 HSD17B10 300/4885NOS1 240/4885ALDH1A1 266/4885
US-20220177460-A1 HMOX1 INDUCERS HMOX1, HMOX2, HMBS HSD17B10 246/4885NOS1 94/4885ALDH1A1 223/4885
US-20080032996-A1 Substituted Quinazoline or Pyridopyrimidine Derivative GCK, GCKR, PDXK HSD17B10 2194/4885NOS1 1000/4885ALDH1A1 1558/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.