Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5370096 | 0.91 | ALDH1A1 (0.56) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL13748438 | 0.89 | NPC1 (0.62) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL12159688 | 0.89 | KMT2A (0.58) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL10252731 | 0.89 | ALDH1A1 (0.53) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL28488994 | 0.87 | ERCC5 (0.60) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL5754659 | 0.87 | RAB9A (0.59) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL294341 | 0.86 | ALDH1A1 (0.73) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL16321874 | 0.86 | ALDH1A1 (0.57) | ALDH1A1KMT2AL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL5751558 | 0.85 | ALDH1A1 (0.66) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL8069055 | 0.84 | ALDH1A1 (0.70) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735178-B2 | Withanolides, probes and binding targets and methods of use thereof | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-05-27 | — | — | US | claimed |
| US-20080207574-A1 | WITHANOLIDES, PROBES AND BINDING TARGETS AND METHODS OF USE THEREOF | KENTUCKY RESEARCH FOUNDATION | 2008-08-28 | — | — | US | claimed |
| WO-2008101109-A1 | WITHANOLIDES, PROBES AND BINDING TARGETS AND METHODS OF USE THEREOF | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2008-08-21 | — | — | WO | claimed |
| CN-109053678-B | Preparation method of benzo [ b ] thiophene-3 (2H) -ketone-1, 1-dioxide | 乐平市科乐化学科技有限公司 | 2022-05-27 | — | — | CN | disclosed |
| US-20180327695-A1 | PHOTOLABILE PRO-FRAGRANCES | HENKEL AG & CO. KGAA (DE) | 2018-11-15 | — | — | US | disclosed |
| US-9926258-B2 | Photolabile pro-fragrances | HENKEL AG & CO. KGAA (DE) | 2018-03-27 | — | — | US | disclosed |
| US-9926258-B2 | Photolabile pro-fragrances | HENKEL AG & CO. KGAA (DE) | 2018-03-27 | — | — | US | disclosed |
| US-9926258-B2 | Photolabile pro-fragrances | HENKEL AG & CO. KGAA (DE) | 2018-03-27 | — | — | US | disclosed |
| WO-2017071874-A1 | PHOTOLABILE PRO-FRAGRANCES | HENKEL AG & CO. KGAA (DE) | 2017-05-04 | — | — | WO | disclosed |
| US-20160347704-A1 | PHOTOLABILE PRO-FRAGRANCES | HENKEL AG & CO. KGAA (DE) | 2016-12-01 | — | — | US | disclosed |
| US-20160347704-A1 | PHOTOLABILE PRO-FRAGRANCES | HENKEL AG & CO. KGAA (DE) | 2016-12-01 | — | — | US | disclosed |
| WO-2015124671-A1 | PHOTOLABILE PRO-FRAGRANCES | HENKEL AG & CO. KGAA (DE) | 2015-08-27 | — | — | WO | disclosed |
| US-8735178-B2 | Withanolides, probes and binding targets and methods of use thereof | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-05-27 | — | — | US | disclosed |
| US-20080207574-A1 | WITHANOLIDES, PROBES AND BINDING TARGETS AND METHODS OF USE THEREOF | KENTUCKY RESEARCH FOUNDATION | 2008-08-28 | — | — | US | disclosed |
| WO-2008101109-A1 | WITHANOLIDES, PROBES AND BINDING TARGETS AND METHODS OF USE THEREOF | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2008-08-21 | — | — | WO | disclosed |
| EP-0871444-A4 | 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 1999-01-13 | — | — | EP | disclosed |
| US-5837719-A | USEFUL FOR TREATING CYTOKINE MEDIATED DISEASES, INFLAMMATION,SHOCK, ARTHRITIS, RESPIRATORY DISORDERS, THROMBOSIS, VIRAL INFECTION, GASTROINTESTINAL DISORDERS | MERCK & CO., INC. (US) | 1998-11-17 | — | — | US | disclosed |
| EP-0871444-A1 | 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997016441-A1 | SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 1997-05-09 | — | — | WO | disclosed |
| WO-1997005878-A1 | 2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 1997-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347704-A1 | PHOTOLABILE PRO-FRAGRANCES | CUTA, FAAH, FAAH2 | ALDH1A1 94/4885KMT2A 977/4885TDP1 3111/4885 |
| US-20180327695-A1 | PHOTOLABILE PRO-FRAGRANCES | CUTA, CRY1, LAGE3 | ALDH1A1 270/4885KMT2A 2087/4885TDP1 2437/4885 |
| US-20080207574-A1 | WITHANOLIDES, PROBES AND BINDING TARGETS AND METHODS OF USE THEREOF | VIM, HASPIN, FABP3 | ALDH1A1 2226/4885KMT2A 3568/4885TDP1 4635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.