Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.91 |
| ▸ | THRB | P10828 | 2/20 | 0.91 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.91 |
| ▸ | SNCA | P37840 | 3/20 | 0.50 |
| ▸ | CHAT | P28329 | 1/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | DNASE1L3 | Q13609 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anazolene SCHEMBL1476742 | 0.95 | MEN1 (1.00) | MEN1THRBKMT2ASNCACHAT | |
| Anazolene SCHEMBL29375317 | 0.95 | MEN1 (1.00) | MEN1THRBKMT2ASNCACHAT | |
| Anazolene SCHEMBL29387597 | 0.95 | MEN1 (1.00) | MEN1THRBKMT2ASNCACHAT | |
| Anazolene SCHEMBL11148088 | 0.95 | MEN1 (1.00) | MEN1THRBKMT2ASNCACHAT | |
| Anazolene SCHEMBL26460213 | 0.95 | MEN1 (1.00) | MEN1THRBKMT2ASNCACHAT | |
| Anazolene SCHEMBL23595 | 0.94 | MEN1 (0.98) | MEN1THRBKMT2ASNCACHAT | |
| Anazolene SCHEMBL23594 | 0.83 | KMT2A (0.76) | MEN1THRBKMT2ASNCACHAT | |
| Anazolene SCHEMBL29374551 | 0.83 | KMT2A (0.76) | MEN1THRBKMT2ASNCACHAT | |
| Anazolene SCHEMBL1649427 | 0.83 | KMT2A (0.76) | MEN1THRBKMT2ASNCACHAT | |
| SCHEMBL12177943 | 0.79 | MEN1 (0.71) | MEN1THRBKMT2ASNCACHAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230127304-A1 | NEW INHIBITORS FOR THE KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230127304-A1 | NEW INHIBITORS FOR THE KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | KEAP1, HMOX1, NFE2L2 | MEN1 4181/4885THRB 3076/4885KMT2A 2474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.