Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Anazolene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | DUSP5 | Q16690 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | CHAT | P28329 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.42 |
| ▸ | APEX1 | P27695 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DNASE1L3 | Q13609 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anazolene SCHEMBL23594 | 1.00 | KMT2A (0.76) | KMT2AMEN1THRBDUSP5PTPN1 | |
| Anazolene SCHEMBL29374551 | 1.00 | KMT2A (0.76) | KMT2AMEN1THRBDUSP5PTPN1 | |
| Anazolene SCHEMBL26460213 | 0.87 | MEN1 (1.00) | KMT2AMEN1THRBCHATSNCA | |
| Anazolene SCHEMBL1476742 | 0.87 | MEN1 (1.00) | KMT2AMEN1THRBCHATSNCA | |
| Anazolene SCHEMBL11148088 | 0.87 | MEN1 (1.00) | KMT2AMEN1THRBCHATSNCA | |
| Anazolene SCHEMBL29375317 | 0.87 | MEN1 (1.00) | KMT2AMEN1THRBCHATSNCA | |
| Anazolene SCHEMBL29387597 | 0.87 | MEN1 (1.00) | KMT2AMEN1THRBCHATSNCA | |
| Anazolene SCHEMBL23595 | 0.86 | MEN1 (0.98) | KMT2AMEN1THRBCHATSNCA | |
| SCHEMBL26459262 | 0.83 | MEN1 (0.91) | KMT2AMEN1THRBCHATSNCA | |
| SCHEMBL11112899 | 0.82 | KMT2A (0.56) | KMT2AMEN1THRBDUSP5PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022188373-A1 | METHOD FOR DETECTING WATER-SOLUBLE ANIONIC SYNTHETIC PIGMENT IN FOOD | 广州市食品检验所（广州市酒类检测中心） | 2022-09-15 | — | — | WO | disclosed |
| US-20210115489-A1 | NOVEL MEDIATOR | KIKKOMAN CORPORATION (JP) | 2021-04-22 | — | — | US | disclosed |
| EP-3780207-A1 | NOVEL MEDIATOR | Kikkoman Corporation (JP) | 2021-02-17 | — | — | EP | disclosed |
| US-10589003-B2 | Methods for coating surfaces with antimicrobial agents | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-03-17 | — | — | US | disclosed |
| US-20180303977-A1 | METHODS FOR COATING SURFACES WITH ANTIMICROBIAL AGENTS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-10-25 | — | — | US | disclosed |
| US-20170035683-A1 | NON-AQUEOUS HAIR BLEACHING AND COLORING COMPOSITIONS, METHODS OF MANUFACTURING SAME AND METHODS OF USE | BRIGHT INTERNATIONAL CORP. (US) | 2017-02-09 | — | — | US | disclosed |
| WO-2015160841-A1 | NON-AQUEOUS HAIR BLEACHING AND COLORING COMPOSITIONS, METHODS OF MANUFACTURING SAME AND METHODS OF USE | BRIGHT INTERNATIONAL CORP. (US) | 2015-10-22 | — | — | WO | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-7713472-B2 | Antiseptic derivatives with broad spectrum antimicrobial activity for the impregnation of surfaces | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-05-11 | — | — | US | disclosed |
| US-20070154621-A1 | METHODS FOR COATING SURFACES WITH ANTIMICROBIAL AGENTS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2007-07-05 | — | — | US | disclosed |
| US-20050197634-A1 | Methods for coating and impregnating medical devices with antiseptic compositions | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2005-09-08 | — | — | US | disclosed |
| US-6200817-B1 | PH and amine test elements and applications to diagnosis of vaginal infections | LITMUS CONCEPTS, INC. | 2001-03-13 | — | — | US | disclosed |
| US-6113856-A | Method of making a pH and amine test element | LITMUS CONCEPTS, INC. (US) | 2000-09-05 | — | — | US | disclosed |
| US-6099801-A | pH and amine test elements and applications to diagnosis of vaginal infections | LITMUS CONCEPTS, INC. (US) | 2000-08-08 | — | — | US | disclosed |
| EP-0925501-A1 | pH AND AMINE TEST ELEMENTS AND APPLICATIONS TO DIAGNOSIS OF VAGINAL INFECTIONS | LITMUS CONCEPTS, INC. (US) | 1999-06-30 | — | — | EP | disclosed |
| US-5910447-A | pH and amine test to diagnosis of vaginal infections | LITMUS CONCEPTS, INC. (US) | 1999-06-08 | — | — | US | disclosed |
| US-5897834-A | pH test elements | LITMUS CONCEPTS, INC. (US) | 1999-04-27 | — | — | US | disclosed |
| WO-1998007027-A1 | pH AND AMINE TEST ELEMENTS AND APPLICATIONS TO DIAGNOSIS OF VAGINAL INFECTIONS | LITMUS CONCEPTS, INC. (US) | 1998-02-19 | — | — | WO | disclosed |
| US-5660790-A | PH and amine test elements | LITMUS CONCEPTS, INC. (US) | 1997-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115489-A1 | NOVEL MEDIATOR | MPO, EPX, LPO | THRB 4364/4885KMT2A 3104/4885MEN1 2351/4885 |
| US-10589003-B2 | Methods for coating surfaces with antimicrobial agents | CUTA, CD63, CDC37 | THRB 4713/4885KMT2A 3316/4885MEN1 4111/4885 |
| US-20180303977-A1 | METHODS FOR COATING SURFACES WITH ANTIMICROBIAL AGENTS | CUTA, CD63, CDC37 | THRB 4713/4885KMT2A 3316/4885MEN1 4111/4885 |
| US-20170035683-A1 | NON-AQUEOUS HAIR BLEACHING AND COLORING COMPOSITIONS, METHODS OF MANUFACTURING SAME AND METHODS OF USE | SMOX, TET2, TST | THRB 3469/4885KMT2A 1342/4885MEN1 2265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.