Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 5/20 | 0.37 |
| ▸ | CNR1 | P21554 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5950550 | 0.94 | MEN1 (0.44) | TSHRMEN1KMT2ACNR2CNR1 | |
| SCHEMBL11457726 | 0.93 | MEN1 (0.39) | TSHRMEN1KMT2ACNR2CNR1 | |
| SCHEMBL20933032 | 0.87 | GABRA1 (0.48) | TSHRMEN1KMT2ACNR2CNR1 | |
| SCHEMBL19507024 | 0.85 | MEN1 (0.38) | TSHRMEN1KMT2ACNR2CNR1 | |
| SCHEMBL20569873 | 0.84 | MEN1 (0.37) | TSHRMEN1KMT2ACYP3A4ALDH1A1 | |
| SCHEMBL24592554 | 0.79 | MEN1 (0.33) | MEN1KMT2AHSD11B1CYP11B2TNKS | |
| SCHEMBL31401375 | 0.79 | TPMT (0.59) | TSHRTPMT | |
| SCHEMBL30457925 | 0.79 | ERN1 (0.36) | MEN1KMT2AHSD11B1ALDH1A1HSD17B10 | |
| SCHEMBL24480874 | 0.79 | L3MBTL1 (0.37) | MEN1KMT2AHSD11B1CYP11B2 | |
| SCHEMBL30602887 | 0.79 | L3MBTL1 (0.37) | MEN1KMT2AHSD11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | claimed |
| EP-0090875-B1 | SEPARATION OF 3,5-DICHLOROCUMENE FROM A MIXTURE OF 3,5-DICHLOROCUMENE AND 2,4-DICHLOROCUMENE | THE DOW CHEMICAL COMPANY (US) | 1985-07-31 | — | — | EP | claimed |
| EP-0061720-B1 | PROCESS FOR THE SELECTIVE ALIPHATIC CHLORINATION OF ALKYLBENZENES | THE DOW CHEMICAL COMPANY (US) | 1985-03-13 | — | — | EP | claimed |
| US-9718817-B2 | Aryl and heteroaryl ether compounds as ROR gamma modulators | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-08-01 | — | — | US | disclosed |
| EP-3131880-A1 | ARYL AND HETEROARYL ETHER COMPOUNDS AS ROR GAMMA MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2017-02-22 | — | — | EP | disclosed |
| US-20170022195-A1 | ARYL AND HETEROARYL ETHER COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-01-26 | — | — | US | disclosed |
| WO-2015159233-A1 | ARYL AND HETEROARYL ETHER COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-10-22 | — | — | WO | disclosed |
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| EP-1463715-A1 | NOVEL GLUCAGON ANTAGONISTS | NOVO NORDISK A/S (DK) | 2004-10-06 | — | — | EP | disclosed |
| US-6762318-B2 | CARBOXYLIC ACID OR TETRAZOLE DERIVATIZED SECONDARY AMIDES; ORAL ADMINISTRATION | NOVO NORDISK A/S (DK) | 2004-07-13 | — | — | US | disclosed |
| US-20030236292-A1 | Stimulant releasing glucose from liver cells; antidiabetic agents | PFIZER INC | 2003-12-25 | — | — | US | disclosed |
| WO-2003048109-A1 | NOVEL GLUCAGON ANTAGONISTS | NOVO NORDISK A/S (DK) | 2003-06-12 | — | — | WO | disclosed |
| EP-0372586-B1 | Cyclic amide compounds and herbicides | KUMIAI CHEMICAL INDUSTRY CO (JP) | 1995-04-26 | — | — | EP | disclosed |
| US-5076834-A | 1,2,5,6-TETRAHYDROPYRIDINE-2-ONE COMPOUNDS WHICH ARE USEFUL HERBICIDES | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1991-12-31 | — | — | US | disclosed |
| US-5006157-A | Pyrrolin-2-one compounds which are useful as herbicides | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1991-04-09 | — | — | US | disclosed |
| EP-0372586-A2 | Cyclic amide compounds and herbicides | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1990-06-13 | — | — | EP | disclosed |
| US-4594467-A | DEHYDROBROMINATING ALPH-BROMO-3,5-DICHLORO CUMENE WITH ALKALI METAL HYDROXIDE IN PRESENCE OF PHASE TRANSFER CATALYST | BAYER AKTIENGESELLSCHAFT (DE) | 1986-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236292-A1 | Stimulant releasing glucose from liver cells; antidiabetic agents | GPR119, GLP1R, GIPR | TSHR 99/4885MEN1 2548/4885KMT2A 4214/4885 |
| US-20170022195-A1 | ARYL AND HETEROARYL ETHER COMPOUNDS AS ROR GAMMA MODULATORS | RORB, RORA, RORC | TSHR 261/4885MEN1 4726/4885KMT2A 1211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.