Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.36 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31092882 | 0.85 | LMNA (0.44) | AKR1C3AKR1C2KDM4ENOTUMUSP2 | |
| SCHEMBL26488238 | 0.85 | LMNA (0.44) | AKR1C3AKR1C2KDM4ENOTUMUSP2 | |
| SCHEMBL22093638 | 0.82 | CES2 (0.45) | KDM4EMAPTKMT2ALMNA | |
| SCHEMBL12439663 | 0.80 | SLC6A9 (0.46) | — | |
| SCHEMBL12439665 | 0.78 | SLC9A1 (0.42) | — | |
| SCHEMBL421721 | 0.78 | CA12 (0.52) | AKR1C3AKR1C2KDM4ENOTUMUSP2 | |
| SCHEMBL22093825 | 0.77 | DGAT1 (0.43) | MAP2K1TGFBR1ACVR1KDM4EPOLB | |
| SCHEMBL26486063 | 0.77 | MAP2K1 (0.43) | MAP2K1TGFBR1ACVR1KDM4EPOLB | |
| SCHEMBL423901 | 0.76 | GPR35 (0.41) | AKR1C3AKR1C2KDM4ENOTUMMAPT | |
| SCHEMBL14817465 | 0.76 | NOTUM (0.51) | AKR1C3AKR1C2KDM4ENOTUMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024217493-A1 | CRYSTALLINE METHIONINE ADENOSYLTRANSFERASE 2a (MAT2A) INHIBITOR AND USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2024-10-24 | — | — | WO | disclosed |
| WO-2023066283-A1 | METHIONINE ADENOSYLTRANSFERASE 2A (MAT2A) INHIBITORS AND USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2023-04-27 | — | — | WO | disclosed |