Sugi Predict

Sugi Predict / Compounds / SCHEMBL265111

SCHEMBL265111

SCHEMBL265111

O=c1[nH]n(-c2ccccc2)c(=O)c2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 1.00
▸ MPI P34949 1/20 0.66
▸ MEN1 O00255 5/20 0.65
▸ KMT2A Q03164 5/20 0.65
▸ POLB P06746 1/20 0.65
▸ PLEC Q15149 1/20 0.65
▸ LDHA P00338 1/20 0.59
▸ KDM4E B2RXH2 1/20 0.57
▸ TP53 P04637 1/20 0.57
▸ GAA P10253 3/20 0.56
▸ MAPK1 P28482 2/20 0.56
▸ GLS O94925 1/20 0.51
▸ LMNA P02545 1/20 0.51
▸ ALOX15 P16050 1/20 0.49
▸ CYP1A2 P05177 1/20 0.47
▸ CYP3A4 P08684 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ CYP2C19 P33261 1/20 0.47
▸ HTT P42858 1/20 0.47
▸ NPC1 O15118 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31384289 1.00 TSHR (1.00) TSHRMPIMEN1KMT2APOLB
SCHEMBL30540389 0.85 TSHR (0.73) TSHRMPIMEN1KMT2APOLB
SCHEMBL20945141 0.85 TSHR (0.73) TSHRMPIMEN1KMT2APOLB
SCHEMBL4066743 0.85 TSHR (0.73) TSHRMPIMEN1KMT2APOLB
SCHEMBL30471655 0.85 TSHR (0.73) TSHRMPIMEN1KMT2APOLB
SCHEMBL28666827 0.85 TSHR (0.73) TSHRMPIMEN1KMT2APOLB
SCHEMBL4063980 0.84 TSHR (0.72) TSHRMPIMEN1KMT2APOLB
SCHEMBL10969803 0.82 TSHR (0.69) TSHRMPIMEN1KMT2APOLB
SCHEMBL9000975 0.81 TSHR (0.67) TSHRMPIMEN1KMT2APOLB
SCHEMBL22721901 0.81 TSHR (0.67) TSHRMPIMEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116574029-A Method for synthesizing azobenzene from diaryl iodonium salt 桂林理工大学 2023-08-11 — — CN claimed
EP-1655070-B1 OXIDATION CATALYST ASAHI KASEI CHEMICALS CORP (JP) 2015-07-15 — — EP claimed
US-8133834-B2 Oxidation catalyst ASAHI KASEI CHEMICALS CORPORATION (JP) 2012-03-13 — — US claimed
US-20100069670-A1 Oxidation catalyst ASAHI KASEI CHEMICALS CORPORATION (JP) 2010-03-18 — — US claimed
US-20060229471-A1 Oxidation catalyst ASAHI KASEI CHEMICALS CORPORATION (JP) 2006-10-12 — — US claimed
EP-1655070-A1 OXIDATION CATALYST Asahi Kasei Chemicals Corporation (JP) 2006-05-10 — — EP claimed
US-4861778-A 2,3-dihydrophthalazine-1,4-diones RESEARCH CORPORATION (US) 1989-08-29 — — US claimed
US-4207112-A STORAGE STABILITY FUJI PHOTO FILM CO., LTD. (JP) 1980-06-10 — — US claimed
CN-113754558-B Method for synthesizing azobenzene through copper salt catalyzed C-N coupling reaction 桂林理工大学 2023-06-23 — — CN disclosed
US-20230159469-A1 NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF TXINNO BIOSCIENCE INC. (KR) 2023-05-25 — — US disclosed
US-20230159469-A1 NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF TXINNO BIOSCIENCE INC. (KR) 2023-05-25 — — US disclosed
US-20230159469-A1 NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF TXINNO BIOSCIENCE INC. (KR) 2023-05-25 — — US disclosed
EP-4148046-A1 NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE INHIBITORY ACTIVITY, AND USE THEREOF Txinno Bioscience Inc. (KR) 2023-03-15 — — EP disclosed
CN-115515939-A Novel phthalazine derivatives having an inhibitory activity on ectonucleotide pyrophosphatase-phosphodiesterase and their use 谛希诺生物科技有限公司 2022-12-23 — — CN disclosed
US-20060089359-A1 Phthalazinone derivatives F. HOFFMANN-LA ROCHE AG (CH) 2006-04-27 — — US disclosed
WO-2006032518-A1 NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2006-03-30 — — WO disclosed
US-4861778-A 2,3-dihydrophthalazine-1,4-diones RESEARCH CORPORATION (US) 1989-08-29 — — US disclosed
US-4772747-A Preparation of 2,4,6-trichlorophenylhydrazine EASTMAN KODAK COMPANY (US) 1988-09-20 — — US disclosed
US-4207112-A STORAGE STABILITY FUJI PHOTO FILM CO., LTD. (JP) 1980-06-10 — — US disclosed
US-4076534-A Heat developable light-sensitive material FUJI PHOTO FILM CO., LTD. (JA) 1978-02-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060089359-A1 Phthalazinone derivatives SDHA, SDHB, CYP3A5 TSHR 4156/4885MPI 2445/4885MEN1 657/4885
US-20100069670-A1 Oxidation catalyst PPOX, SOD1, HAO2 TSHR 4696/4885MPI 763/4885MEN1 4765/4885
US-20230159469-A1 NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF ENPP1, ENPP3, PPA1 TSHR 3987/4885MPI 1783/4885MEN1 644/4885
US-20060229471-A1 Oxidation catalyst PPOX, SOD1, HAO2 TSHR 4696/4885MPI 763/4885MEN1 4765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.