Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26525002 | 0.80 | NLRP3 (0.35) | LMNAKMT2ANLRP3SMN1; SMN2 | |
| SCHEMBL11542153 | 0.73 | LMNA (0.38) | LMNAKMT2AGABRA1GABRB2NLRP3 | |
| SCHEMBL24704695 | 0.70 | KMT2A (0.36) | LMNAKMT2AGABRA1GABRB2NLRP3 | |
| SCHEMBL24502399 | 0.68 | — | — | |
| SCHEMBL25783337 | 0.64 | GABRA1 (0.48) | LMNAKMT2AGABRA1GABRB2SMN1; SMN2 | |
| SCHEMBL27873162 | 0.64 | LMNA (0.38) | LMNAKMT2AGABRA1GABRB2SMN1; SMN2 | |
| SCHEMBL3723323 | 0.62 | GABRA1 (0.42) | LMNAKMT2AGABRA1GABRB2POLB | |
| SCHEMBL78109 | 0.62 | SIGMAR1 (0.42) | LMNAKMT2AGABRA1GABRB2SMN1; SMN2 | |
| SCHEMBL2624369 | 0.62 | TSPO (0.49) | LMNAKMT2AGABRA1GABRB2SMN1; SMN2 | |
| SCHEMBL24193546 | 0.62 | KMT2A (0.37) | LMNAKMT2AGABRA1GABRB2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3788038-B1 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | AMGEN INC (US) | 2023-10-11 | — | — | EP | disclosed |