Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 3/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653267 | 0.83 | CA2 (0.38) | PTGDR2CYP3A4CTDSP1POLB | |
| SCHEMBL2652919 | 0.81 | CNR2 (0.36) | PTGDR2ALDH1A1CYP3A4POLB | |
| SCHEMBL2652827 | 0.76 | PTGS2 (0.42) | ALDH1A1CYP3A4TBXA2R | |
| SCHEMBL2653280 | 0.75 | PTGS2 (0.44) | ALDH1A1CYP3A4TBXA2R | |
| SCHEMBL7296588 | 0.72 | ALDH1A1 (0.59) | STAT3ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1582479 | 0.71 | ALDH1A1 (0.39) | STAT3ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14098638 | 0.70 | EPHX2 (0.55) | STAT3ALDH1A1CYP2C9CYP2C19CTDSP1 | |
| SCHEMBL2653194 | 0.66 | CYP3A4 (0.39) | PTGDR2CYP3A4 | |
| SCHEMBL1148919 | 0.65 | ALDH1A1 (0.46) | STAT3ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2653490 | 0.65 | CYP3A4 (0.41) | PTGDR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |