Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653280 | 0.86 | PTGS2 (0.44) | ALDH1A1KMT2ALMNASLC6A2SLC6A4 | |
| SCHEMBL2652827 | 0.85 | PTGS2 (0.42) | ALDH1A1KMT2ALMNASLC6A2SLC6A4 | |
| SCHEMBL2652919 | 0.81 | CNR2 (0.36) | ALDH1A1KMT2ALMNASMN1; SMN2POLB | |
| SCHEMBL2653267 | 0.77 | CA2 (0.38) | POLBCYP3A4 | |
| SCHEMBL2654132 | 0.76 | PTGS2 (0.41) | ALDH1A1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2653490 | 0.76 | CYP3A4 (0.41) | KMT2AMEN1CYP3A4KDM4EMAPT | |
| SCHEMBL2654413 | 0.76 | PTGDR2 (0.51) | KMT2ASMN1; SMN2MEN1POLBCYP3A4 | |
| SCHEMBL2653153 | 0.76 | ALDH1A1 (0.54) | ALDH1A1KMT2ALMNASMN1; SMN2MEN1 | |
| SCHEMBL2655512 | 0.75 | PTGDR2 (0.55) | KMT2AMEN1CYP3A4MAPT | |
| SCHEMBL2653863 | 0.75 | RAB9A (0.48) | ALDH1A1KMT2ALMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |