Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26550285 | 0.92 | MAPK14 (0.41) | HTR7ADRB2FDPSMAPK14ADRA1D | |
| SCHEMBL26548755 | 0.82 | KDM4E (0.44) | HTR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL26548744 | 0.81 | NOS1 (0.44) | HTR7FDPSMAPK14MAPK10HRH4 | |
| SCHEMBL26550287 | 0.81 | CHRNB2 (0.44) | HTR7ALDH1A1 | |
| SCHEMBL19728670 | 0.80 | RIOK2 (0.48) | ALDH1A1MAPK10RIOK2 | |
| SCHEMBL19736190 | 0.78 | ALDH1A1 (0.46) | MAPK14ALDH1A1RIOK2 | |
| SCHEMBL26548519 | 0.77 | CCR1 (0.52) | FDPSMAPK14MAPK10HRH4RIOK2 | |
| SCHEMBL26547682 | 0.76 | CYP2C9 (0.43) | HTR7MAPK14ALDH1A1MAPK10HRH4 | |
| SCHEMBL26550280 | 0.76 | FDPS (0.48) | HTR7FDPSMAPK14ALDH1A1MAPK10 | |
| SCHEMBL19728667 | 0.72 | RIOK2 (0.49) | ALDH1A1MAPK10RIOK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196975-A1 | COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2023-10-12 | — | — | WO | disclosed |