Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | CD44 | P16070 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9073026 | 0.82 | CYP3A4 (0.46) | S1PR1IDO1PNMTSMN1; SMN2RAPGEF4 | |
| SCHEMBL1291043 | 0.79 | TTR (0.40) | S1PR1MCL1IDO1PTPN7DUSP3 | |
| SCHEMBL12643 | 0.79 | TRPA1 (0.43) | S1PR1MCL1IDO1PTPN7DUSP3 | |
| P-Xylene SCHEMBL28217852 | 0.78 | IDO1 (0.38) | S1PR1IDO1KMT2ASMN1; SMN2CD44 | |
| SCHEMBL2622769 | 0.78 | ALDH1A1 (0.40) | ESR1ESR2KMT2APTGS1PTGS2 | |
| SCHEMBL9788481 | 0.78 | IDO1 (0.58) | IDO1PNMTSMN1; SMN2TAAR1 | |
| SCHEMBL3753927 | 0.77 | S1PR1 (0.38) | S1PR1MCL1IDO1PTPN7DUSP3 | |
| SCHEMBL93063 | 0.77 | S1PR1 (0.51) | S1PR1MCL1PTPN7DUSP3ESR1 | |
| SCHEMBL3128100 | 0.77 | CSNK2A1 (0.47) | S1PR1PNMTKMT2ASMN1; SMN2CD44 | |
| SCHEMBL583557 | 0.77 | CYP4F2 (0.50) | S1PR1MCL1IDO1PTPN7DUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170088548-A1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-03-30 | — | — | US | disclosed |
| US-9382232-B2 | Quinoline and cinnoline derivatives and their applications | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2016-07-05 | — | — | US | disclosed |
| US-20160083358-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2016-03-24 | — | — | US | disclosed |
| US-20140364431-A1 | Quinoline and cinnoline derivatives and their applications | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2014-12-11 | — | — | US | disclosed |
| WO-2000039088-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088548-A1 | PYRAZOLOPYRIDINE SULFONAMIDES AS NEMATICIDES | NISCH, CATSPER1, KCNH1 | S1PR1 1111/4885MCL1 1832/4885IDO1 2759/4885 |
| US-20140364431-A1 | Quinoline and cinnoline derivatives and their applications | MET, CHEK1, KIT | S1PR1 2124/4885MCL1 499/4885IDO1 3631/4885 |
| US-20160083358-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | ATXN10, ATXN2, ATXN2L | S1PR1 4394/4885MCL1 1020/4885IDO1 4090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.