Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2664261 | 0.84 | SMN1; SMN2 (0.52) | PTGS2PTGS1HTTTDP1L3MBTL1 | |
| SCHEMBL9071200 | 0.84 | PTGS2 (0.46) | PTGS2PTGS1S1PR2NR1H2NR1H3 | |
| SCHEMBL12929412 | 0.82 | ALDH1A1 (0.50) | HTTTDP1L3MBTL1LMNAPOLB | |
| SCHEMBL7990329 | 0.82 | PTGS2 (0.57) | PTGS2PTGS1CYP11B1CYP11B2 | |
| SCHEMBL9071207 | 0.81 | PTGS2 (0.43) | PTGS2PTGS1S1PR2CYP11B1CYP11B2 | |
| SCHEMBL8941664 | 0.79 | NR3C1 (0.53) | PTGS2PTGS1NR1H2NR1H3HTT | |
| SCHEMBL12173156 | 0.78 | ALDH1A1 (0.70) | TDP1L3MBTL1POLBMAPTSMN1; SMN2 | |
| SCHEMBL21958839 | 0.78 | LMNA (0.46) | L3MBTL1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL24512621 | 0.78 | ALDH1A1 (0.43) | L3MBTL1LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL2664245 | 0.77 | ENPP2 (0.48) | PTGS2PTGS1HTTTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812048-B2 | Glucokinase activators and methods of using same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-10-12 | — | — | US | disclosed |
| US-20090030046-A1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | BRISTOL-MYERS SQUIBB COMPANY | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030046-A1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | GCKR, GCK, HK1 | PTGS2 3643/4885PTGS1 3025/4885S1PR2 2251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.