Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL863126 | 0.88 | PTGS2 (0.68) | PTGS2CYP11B1CYP11B2CA1CA2 | |
| SCHEMBL11547843 | 0.84 | HTT (0.58) | PTGS2PTGS1 | |
| SCHEMBL8941579 | 0.83 | SMN1; SMN2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL2664281 | 0.82 | PTGS2 (0.49) | PTGS2CYP11B1CYP11B2PTGS1 | |
| SCHEMBL8941664 | 0.82 | NR3C1 (0.53) | PTGS2MMP2MMP9PTGS1KIF11 | |
| SCHEMBL7506839 | 0.82 | PTGS2 (0.72) | PTGS2AKR1C3KIF11 | |
| SCHEMBL6925883 | 0.81 | PTGS2 (0.60) | PTGS2MMP2MMP9KIF11MMP1 | |
| SCHEMBL3106187 | 0.81 | CA1 (0.50) | PTGS2CA1CA2CA9MMP2 | |
| SCHEMBL29839201 | 0.81 | ALDH1A1 (0.70) | PTGS2CA1CA2CA9PTGS1 | |
| SCHEMBL30868599 | 0.81 | CA1 (0.50) | CA1CA2CA9MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |