Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.66 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | IARS1 | P41252 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL8856617 | 0.86 | GCGR (0.52) | MEN1KMT2ASLC22A6SLC22A8RAB9A | |
| SCHEMBL4162113 | 0.86 | PDE4D (0.58) | MEN1KMT2AHTTCYP1A2BLM | |
| SCHEMBL2086007 | 0.86 | MEN1 (0.66) | MEN1KMT2ASLC22A6SLC22A8RAB9A | |
| SCHEMBL29412632 | 0.86 | CYP1A2 (0.63) | MEN1KMT2ARAB9ACYP1A2KDM4E | |
| SCHEMBL2446906 | 0.86 | CYP1A2 (0.63) | MEN1KMT2ARAB9ACYP1A2KDM4E | |
| Hydrochloric Acid SCHEMBL3566445 | 0.85 | PDE4D (0.57) | MEN1KMT2AHTTCYP1A2BLM | |
| SCHEMBL1437123 | 0.84 | SLC22A6 (0.68) | MEN1KMT2ASLC22A6SLC22A8RAB9A | |
| SCHEMBL5758000 | 0.84 | MEN1 (0.68) | MEN1KMT2ASLC22A6SLC22A8RAB9A | |
| SCHEMBL13216467 | 0.83 | RAB9A (0.62) | MEN1KMT2ASLC22A6SLC22A8RAB9A | |
| SCHEMBL28325208 | 0.83 | MEN1 (0.62) | MEN1KMT2ASLC22A6SLC22A8RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102775370-B | Thiazole compound, its preparation and application | INST OCEANOLOGY CHINESE ACAD | 2014-06-18 | — | — | CN | claimed |
| EP-4204401-A1 | COMPOUNDS FOR AND METHODS OF TREATING DISEASES | Alterity Therapeutics Limited (AU) | 2023-07-05 | — | — | EP | disclosed |
| US-11603364-B2 | Acyl hydrazone derivative compounds for treating disease | Alterity Therapeutics Limited (AU) | 2023-03-14 | — | — | US | disclosed |
| WO-2022040747-A1 | COMPOUNDS FOR AND METHODS OF TREATING DISEASES | Alterity Therapeutics Limited (AU) | 2022-03-03 | — | — | WO | disclosed |
| US-20220064142-A1 | COMPOUNDS FOR AND METHODS OF TREATING DISEASES | ADJUVANT BIOTECHNOLOGY PTY LIMITED (AU) | 2022-03-03 | — | — | US | disclosed |
| CN-112079744-B | Aromatic acylhydrazone derivatives and application thereof as NA (adenosine) inhibitor | 湖南大学 | 2021-07-30 | — | — | CN | disclosed |
| CN-112079744-A | Aromatic acylhydrazone derivatives and application thereof as NA (adenosine) inhibitor | 湖南大学 | 2020-12-15 | — | — | CN | disclosed |
| EP-2987533-B1 | 7-substituted piperazin-1-yl fluoroquinolone compounds, their use in the treatment of cancer, pharmaceutical compositions and a method for preparation | UNIV KING SAUD (SA) | 2018-07-11 | — | — | EP | disclosed |
| EP-2987533-A1 | 7-substituted piperazin-1-yl fluoroquinolone compounds, their use in the treatment of cancer, pharmaceutical compositions and a method for preparation | King Saud University (SA) | 2016-02-24 | — | — | EP | disclosed |
| US-20100292334-A1 | N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2010-11-18 | — | — | US | disclosed |
| EP-2222308-A1 | N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NeuroSearch AS (DK) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009065850-A1 | N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2009-05-28 | — | — | WO | disclosed |
| US-20040110963-A1 | Novel hydrazones | ARPIDA AG (CH) | 2004-06-10 | — | — | US | disclosed |
| EP-1404644-A2 | NOVEL HYDRAZONES | Arpida AG, (CH) | 2004-04-07 | — | — | EP | disclosed |
| WO-2002070464-A2 | HYDRAZONES AND THEIR THERAPEUTIC USE | ARPIDA AG (CH) | 2002-09-12 | — | — | WO | disclosed |
| WO-1999001423-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 1999-01-14 | — | — | WO | disclosed |
| EP-0566446-A1 | Derivatives of indane-1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA (FR) | 1993-10-20 | — | — | EP | disclosed |
| WO-1993020046-A1 | INDAN-1,3-DIONE AND INDAN-1,2,3-TRIONE DERIVATIVES, PROCESSES FOR PREPARATION OF SAME AND THEIR USE AS THERAPEUTIC AGENTS | INNOTHERA (FR) | 1993-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11603364-B2 | Acyl hydrazone derivative compounds for treating disease | FH, ACOX1, HDAC1 | MEN1 2244/4885KMT2A 812/4885SLC22A6 475/4885 |
| US-20100292334-A1 | N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA3, CHRNA6, CHRNA2 | MEN1 4104/4885KMT2A 1475/4885SLC22A6 2064/4885 |
| US-20220064142-A1 | COMPOUNDS FOR AND METHODS OF TREATING DISEASES | SLC30A6, SLC39A11, SLC40A1 | MEN1 1259/4885KMT2A 1582/4885SLC22A6 188/4885 |
| US-20040110963-A1 | Novel hydrazones | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HK1, MPO | MEN1 2514/4885KMT2A 3368/4885SLC22A6 3934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.