Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12125059 | 0.89 | POLB (0.34) | POLB | |
| SCHEMBL14115913 | 0.83 | POLB (0.40) | POLBKDM4E | |
| SCHEMBL368782 | 0.82 | APLNR (0.36) | POLBAPLNR | |
| SCHEMBL1861361 | 0.81 | POLB (0.33) | POLB | |
| SCHEMBL1861359 | 0.81 | POLB (0.33) | POLB | |
| SCHEMBL10086734 | 0.79 | GPR119 (0.33) | POLBAPLNR | |
| SCHEMBL22302806 | 0.74 | APLNR (0.30) | APLNR | |
| SCHEMBL935668 | 0.74 | LMNA (0.32) | — | |
| SCHEMBL14446957 | 0.73 | — | — | |
| SCHEMBL26999304 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008080822-A1 | EPIMERIZATION METHODOLOGIES FOR RECOVERING STEREO ISOMERS IN HIGH YIELD AND PURITY | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-10 | — | — | WO | disclosed |
| WO-2008080824-A1 | AROMATIC SULFONATED KETALS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-10 | — | — | WO | disclosed |
| WO-2008080823-A1 | REDUCTION METHODOLOGIES FOR CONVERTING KETAL ACIDS, SALTS, AND ESTERS TO KETAL ALCOHOLS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-10 | — | — | WO | disclosed |
| US-20080161563-A1 | Reduction methodologies for converting ketal acids, salts, and esters to ketal alcohols | ROCHE COLORADO CORPORATION | 2008-07-03 | — | — | US | disclosed |
| US-20080161564-A1 | Aromatic sulfonated ketals | ROCHE COLORADO CORPORATION | 2008-07-03 | — | — | US | disclosed |
| US-20080161583-A1 | Epimerization methodologies for recovering stereoisomers in high yield and purity | ROCHE PALO ALTO LLC | 2008-07-03 | — | — | US | disclosed |
| US-20070254895-A1 | Crystalline solvate of glucokinase activator | CHOI DUK SOON | 2007-11-01 | — | — | US | disclosed |
| US-20070254895-A1 | Crystalline solvate of glucokinase activator | CHOI DUK SOON | 2007-11-01 | — | — | US | disclosed |
| WO-2007115967-A1 | CRYSTALLINE ISOPROPANOL SOLVATE OF GLUCOKINASE ACTIVATOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007115968-A2 | PROCESS FOR THE PREPARATION OF A GLUCOKINASE ACTIVATOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |
| US-20070244129-A1 | Process for the preparation of an isopropanol solvate of a glucokinase activator | DANIEWSKI ANDRZEJ ROBERT | 2007-10-18 | — | — | US | disclosed |
| US-20070244129-A1 | Process for the preparation of an isopropanol solvate of a glucokinase activator | DANIEWSKI ANDRZEJ ROBERT | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161564-A1 | Aromatic sulfonated ketals | KCNJ2, KCNK4, KCNH3 | POLB 4445/4885KDM4E 276/4885PKM 181/4885 |
| US-20080161583-A1 | Epimerization methodologies for recovering stereoisomers in high yield and purity | GALE, PDE8A, CYP51A1 | POLB 1653/4885KDM4E 4004/4885PKM 498/4885 |
| US-20070244129-A1 | Process for the preparation of an isopropanol solvate of a glucokinase activator | GCKR, GCK, GK | POLB 1062/4885KDM4E 3157/4885PKM 288/4885 |
| US-20080161563-A1 | Reduction methodologies for converting ketal acids, salts, and esters to ketal alcohols | ADH1C, ADH1A, KHK | POLB 1312/4885KDM4E 185/4885PKM 90/4885 |
| US-20070254895-A1 | Crystalline solvate of glucokinase activator | GCKR, GCK, PDXK | POLB 3161/4885KDM4E 3869/4885PKM 501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.