Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.42 |
| ▸ | PREP | P48147 | 3/20 | 0.41 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13159232 | 0.95 | PPARA (0.48) | PPARALTA4HEPHX2CYP4A11PREP | |
| SCHEMBL25496223 | 0.94 | PPARA (0.47) | PPARALTA4HEPHX2CYP4A11PREP | |
| SCHEMBL2882151 | 0.90 | PPARA (0.50) | PPARACYP4A11PREPCYP4F2CA12 | |
| SCHEMBL4521924 | 0.85 | PREP (0.42) | PPARAPREPCALM1CA12CA1 | |
| SCHEMBL18653924 | 0.83 | PREP (0.41) | PPARAPREPCALM1CA12CA1 | |
| SCHEMBL318210 | 0.82 | PPARA (0.47) | PPARALTA4HPREPCA12CA1 | |
| SCHEMBL18654007 | 0.82 | PREP (0.40) | PPARAPREPCALM1CA12CA1 | |
| SCHEMBL3843622 | 0.81 | PREP (0.44) | PPARAPREPCALM1CA12CA1 | |
| SCHEMBL1171890 | 0.81 | PREP (0.40) | PPARAPREPCALM1CA12CA1 | |
| SCHEMBL2856721 | 0.80 | PREP (0.43) | PPARALTA4HPREPCALM1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9649373-B2 | Neoseptins: small molecule adjuvants | THE SCRIPPS INSTITUTE (US) | 2017-05-16 | — | — | US | disclosed |
| EP-2855464-B1 | NITRIC OXIDE DONOR NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2016-10-26 | — | — | EP | disclosed |
| US-9045443-B2 | Nitric oxide donor neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-06-02 | — | — | US | disclosed |
| US-8173696-B2 | Inhibitors of cysteine proteases and methods of use thereof | BAYLOR UNIVERSITY (US) | 2012-05-08 | — | — | US | disclosed |
| US-20090076076-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | BAYLOR UNIVERSITY (US) | 2009-03-19 | — | — | US | disclosed |
| US-6492550-B2 | INHIBITORS OF THE CYTOSOLIC PHOSPHOLYPASE A2 ENZYMES | BRISTOL-MYERS SQUIBB COMPANY | 2002-12-10 | — | — | US | disclosed |
| US-20020068722-A1 | Alpha-substituted thio,-oxo trifluoromethylketones as phospholipase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2002-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068722-A1 | Alpha-substituted thio,-oxo trifluoromethylketones as phospholipase inhibitors | PLA2G4B, PLA2G4A, PLA2G1B | PPARA 743/4885LTA4H 55/4885EPHX2 567/4885 |
| US-20090076076-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | CTSB, CTSS, CTSZ | PPARA 3331/4885LTA4H 526/4885EPHX2 2272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.