Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2675352 | 1.00 | KDM4E (0.48) | KDM4EAOC3ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL31070923 | 0.87 | TNF (0.43) | KDM4EALDH1A1TDP1L3MBTL1KMT2A | |
| SCHEMBL15085696 | 0.87 | TNF (0.43) | KDM4EALDH1A1TDP1L3MBTL1KMT2A | |
| SCHEMBL30013379 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1HIF1APKM | |
| SCHEMBL7375715 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1HIF1APKM | |
| SCHEMBL29785614 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1HIF1APKM | |
| SCHEMBL7885274 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1HIF1APKM | |
| SCHEMBL491064 | 0.85 | LDHA (0.54) | KDM4EAOC3ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL28150234 | 0.83 | KDM4E (0.49) | KDM4EAOC3ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL7408009 | 0.82 | HDAC4 (0.52) | KDM4EALDH1A1SMN1; SMN2TAAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173128-B2 | Methods and compositions for inducing apoptosis in cancer cells with an anti-DR5 antibody | IRM LLC (BM) | 2012-05-08 | — | — | US | disclosed |
| CN-1750843-B | Methods and compositions for inducing apoptosis in cancer cells | IRM LLC | 2011-09-28 | — | — | CN | disclosed |
| EP-1576179-B1 | METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS | IRM LLC (BM) | 2010-09-15 | — | — | EP | disclosed |
| CN-100415770-C | 2-{[N-(2-amino-3-(heteroaryl or aryl) propionyl)-aminoacyl]-amino}- alkylboronic acid derivatives | NOVARTIS AG (CH) | 2008-09-03 | — | — | CN | disclosed |
| US-7229617-B2 | Methods and compositions for inducing apoptosis in cancer cells | IRM LLC (BM) | 2007-06-12 | — | — | US | disclosed |
| US-20070128204-A1 | Methods and compositions for inducing apoptosis in cancer cells | IRM LLC (BM) | 2007-06-07 | — | — | US | disclosed |
| EP-1576179-A4 | METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS | IRM LLC (BM) | 2007-06-06 | — | — | EP | disclosed |
| CN-1750843-A | Methods and compositions for inducing apoptosis in cancer cells | IRM LLC (BM) | 2006-03-22 | — | — | CN | disclosed |
| EP-1399468-B1 | 2-((N-(2-AMINO-3-(HETEROARYL OR ARYL)PROPIONYL)-AMINOACYL)-AMINO)-ALKYLBORONIC ACID DERIVATIVES | NOVARTIS AG (CH) | 2006-02-15 | — | — | EP | disclosed |
| US-20050239716-A1 | 2-{[N-(2-amino-3-(heteroaryl or aryl) propionyl)-aminoacyl]-amino}-alkylboronic acid derivatives | FURET PASCAL | 2005-10-27 | — | — | US | disclosed |
| US-20040167337-A1 | 2-{[n-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl}-amino}-alkylboronic acid derivatives | NOVARTIS AG (CH) | 2004-08-26 | — | — | US | disclosed |
| CN-1512999-A | 2-{[N-(2-amino-3-(heteroaryl or aryl) propionyl)-aminoacyl]-amino}- alkylboronic acid derivatives | ��˹��ŵ�� | 2004-07-14 | — | — | CN | disclosed |
| WO-2004050895-A2 | METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS | IRM LLC (BM) | 2004-06-17 | — | — | WO | disclosed |
| EP-1399468-A1 | 2-((N-(2-AMINO-3-(HETEROARYL OR ARYL)PROPIONYL)-AMINOACYL)-AMINO)-ALKYLBORONIC ACID DERIVATIVES | Novartis AG (CH) | 2004-03-24 | — | — | EP | disclosed |
| WO-2002096933-A1 | 2-{[N-(2-AMINO-3-(HETEROARYL OR ARYL)PROPIONYL)-AMINOACYL]-AMINO}-ALKYLBORONIC ACID DERIVATIVES | NOVARTIS AG (CH) | 2002-12-05 | — | — | WO | disclosed |
| EP-0206460-B1 | L-PHENYLALANINE DEHYDROGENASE AND USE THEREOF | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1993-08-11 | — | — | EP | disclosed |
| EP-0513872-A1 | L-phenylalanine dehydrogenase and use thereof | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1992-11-19 | — | — | EP | disclosed |
| EP-0347766-A2 | 4,5,7,8-Tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as medicaments | Dr. Karl Thomae GmbH (DE) | 1989-12-27 | — | — | EP | disclosed |
| US-4849345-A | L-phenylalanine dehydrogenase and use thereof | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0206460-A2 | L-phenylalanine dehydrogenase and use thereof | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1986-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167337-A1 | 2-{[n-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl}-amino}-alkylboronic acid derivatives | AADAT, BCAT1, BCAT2 | KDM4E 3591/4885AOC3 764/4885ALDH1A1 197/4885 |
| US-20050239716-A1 | 2-{[N-(2-amino-3-(heteroaryl or aryl) propionyl)-aminoacyl]-amino}-alkylboronic acid derivatives | AADAT, PIGS, SLC1A5 | KDM4E 3302/4885AOC3 334/4885ALDH1A1 226/4885 |
| US-20070128204-A1 | Methods and compositions for inducing apoptosis in cancer cells | BAD, BAX, BID | KDM4E 4733/4885AOC3 4122/4885ALDH1A1 4161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.