Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | LAP3 | P28838 | 3/20 | 0.40 |
| ▸ | ANPEP | P15144 | 3/20 | 0.40 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.40 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2675827 | 1.00 | CCR1 (0.48) | CCR1MMP1MMP2MMP3LAP3 | |
| SCHEMBL4068030 | 0.90 | MMP2 (0.46) | CCR1MMP1MMP2MMP3LAP3 | |
| SCHEMBL4072357 | 0.88 | CCR1 (0.46) | CCR1MMP1MMP2MMP3LAP3 | |
| SCHEMBL4069510 | 0.87 | CCR1 (0.57) | CCR1MMP1MMP2MMP3LAP3 | |
| SCHEMBL7581428 | 0.87 | CCR1 (0.57) | CCR1MMP1MMP2MMP3LAP3 | |
| SCHEMBL2675968 | 0.84 | MMP1 (0.40) | CCR1MMP1MMP2MMP3LAP3 | |
| SCHEMBL7590174 | 0.84 | MMP1 (0.40) | CCR1MMP1MMP2MMP3LAP3 | |
| SCHEMBL4065396 | 0.82 | REN (0.41) | CCR1MMP1MMP2MMP3LAP3 | |
| SCHEMBL4065351 | 0.81 | LAP3 (0.38) | MMP1MMP2MMP3LAP3ANPEP | |
| SCHEMBL2918534 | 0.80 | TSHR (0.50) | CCR1ANPEPHDAC8MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | claimed |
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | claimed |
| US-20160374945-A1 | PHARMACEUTICAL COMPOSITIONS OF DISPERSIONS OF DRUG AND NEUTRAL POLYMERS | BEND RESEARCH, INC. (US) | 2016-12-29 | — | — | US | disclosed |
| US-9468604-B2 | Pharmaceutical compositions of dispersions of drug and neutral polymers | BEND RESEARCH, INC. (US) | 2016-10-18 | — | — | US | disclosed |
| US-20140210117-A1 | PHARMACEUTICAL COMPOSITIONS OF DISPERSIONS OF DRUG AND NEUTRAL POLYMERS | BEND RESEARCH, INC. (US) | 2014-07-31 | — | — | US | disclosed |
| US-8703199-B2 | Pharmaceutical compositions of adsorbates of amorphous drug | BEND RESEARCH, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703196-B2 | Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers | BEND RESEARCH, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-8491933-B2 | Pharmaceutical compositions of semi-ordered drugs and polymers | BEND RESEARCH, INC. (US) | 2013-07-23 | — | — | US | disclosed |
| US-8389006-B2 | Pharmaceutical compositions of adsorbates of amorphous drug | BEND RESEARCH, INC. (US) | 2013-03-05 | — | — | US | disclosed |
| US-20120322805-A1 | PHARMACEUTICAL COMPOSITIONS OF SEMI-ORDERED DRUGS AND POLYMERS | BEND RESEARCH, INC. (US) | 2012-12-20 | — | — | US | disclosed |
| US-20120295988-A1 | Pharmaceutical Compositions of Dispersions of Amorphous Drugs Mixed with Polymers | BEND RESEARCH, INC. | 2012-11-22 | — | — | US | disclosed |
| US-8173142-B2 | Pharmaceutical compositions of drugs and neutralized acidic polymers | BEND RESEARCH, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |
| US-20090011024-A1 | Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers | PFIZER INC. | 2009-01-08 | — | — | US | disclosed |
| US-20080292707-A1 | Pharmaceutical Compositions of Adsorbates of Amorphous Drug | PFIZER INC | 2008-11-27 | — | — | US | disclosed |
| US-20070148236-A1 | Pharmaceutical Compositions of Adsorbates of Amorphous Drug | PFIZER PRODUCTS INC. | 2007-06-28 | — | — | US | disclosed |
| US-20060216351-A1 | Pharmaceutical Compositions of Dispersions of Drugs and Neutral Polymers | PFIZER INC. | 2006-09-28 | — | — | US | disclosed |
| US-20060204577-A1 | Pharmaceutical Compositions of Drugs and Neutralized Acidic Polymers | PFIZER PRODUCTS INC. | 2006-09-14 | — | — | US | disclosed |
| US-20030054037-A1 | Pharmaceutical compositions of adsorbates of amorphous drug | BEND RESEARCH, INC. | 2003-03-20 | — | — | US | disclosed |
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322805-A1 | PHARMACEUTICAL COMPOSITIONS OF SEMI-ORDERED DRUGS AND POLYMERS | ABCB1, ABCG2, PDE7A | CCR1 1295/4885MMP1 3825/4885MMP2 2952/4885 |
| US-20070148236-A1 | Pharmaceutical Compositions of Adsorbates of Amorphous Drug | ABCG2, ALB, SLCO1A2 | CCR1 1715/4885MMP1 2946/4885MMP2 3198/4885 |
| US-20030054037-A1 | Pharmaceutical compositions of adsorbates of amorphous drug | ABCG2, ALB, SLCO1A2 | CCR1 1715/4885MMP1 2946/4885MMP2 3198/4885 |
| US-20160374945-A1 | PHARMACEUTICAL COMPOSITIONS OF DISPERSIONS OF DRUG AND NEUTRAL POLYMERS | LIPA, ABCG2, ABCB11 | CCR1 3350/4885MMP1 4026/4885MMP2 3623/4885 |
| US-20060204577-A1 | Pharmaceutical Compositions of Drugs and Neutralized Acidic Polymers | PDE7A, CA6, PDE9A | CCR1 1188/4885MMP1 3160/4885MMP2 2164/4885 |
| US-20060216351-A1 | Pharmaceutical Compositions of Dispersions of Drugs and Neutral Polymers | ABCB11, ABCG2, LIPA | CCR1 3210/4885MMP1 4004/4885MMP2 3642/4885 |
| US-20090011024-A1 | Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers | ABCG2, ABCB1, MATR3 | CCR1 3503/4885MMP1 580/4885MMP2 1823/4885 |
| US-20120295988-A1 | Pharmaceutical Compositions of Dispersions of Amorphous Drugs Mixed with Polymers | ABCG2, ABCB1, MATR3 | CCR1 3503/4885MMP1 580/4885MMP2 1823/4885 |
| US-20140210117-A1 | PHARMACEUTICAL COMPOSITIONS OF DISPERSIONS OF DRUG AND NEUTRAL POLYMERS | LIPA, ABCG2, ABCB11 | CCR1 3350/4885MMP1 4026/4885MMP2 3623/4885 |
| US-20080292707-A1 | Pharmaceutical Compositions of Adsorbates of Amorphous Drug | ABCG2, ALB, SLCO1A2 | CCR1 1715/4885MMP1 2946/4885MMP2 3198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.