Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 6/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.51 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924011 | 1.00 | PTGS1 (0.56) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| SCHEMBL2678000 | 1.00 | PTGS1 (0.56) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| SCHEMBL18100905 | 0.81 | PTGS2 (0.60) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| SCHEMBL30578089 | 0.80 | PTGS2 (0.65) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| SCHEMBL29055589 | 0.80 | PTGS2 (0.65) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ammonia Solution, Strong SCHEMBL28229773 | 0.78 | PTGS2 (0.62) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| SCHEMBL14435173 | 0.77 | PTGS2 (0.55) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| SCHEMBL5346565 | 0.77 | PTGS2 (0.54) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| SCHEMBL13681337 | 0.77 | PTGS2 (0.54) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| SCHEMBL24354951 | 0.76 | CHRNA7 (0.50) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563776-B2 | L-Threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120289471-A1 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-11-15 | — | — | US | disclosed |
| US-8188311-B2 | L-threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-05-29 | — | — | US | disclosed |
| US-8173840-B2 | Compounds with high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-05-08 | — | — | US | disclosed |
| US-20100069446-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS (US) | 2010-03-18 | — | — | US | disclosed |
| US-20100069489-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS (US) | 2010-03-18 | — | — | US | disclosed |
| US-20100004481-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS (US) | 2010-01-07 | — | — | US | disclosed |
| US-7589233-B2 | L-Threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2009-09-15 | — | — | US | disclosed |
| WO-2007089745-A2 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | SIGNATURE R & D HOLDINGS, LLC (US) | 2007-08-09 | — | — | WO | disclosed |
| US-20060287244-A1 | L-Threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC | 2006-12-21 | — | — | US | disclosed |
| US-20060241017-A1 | Novel compounds with high therapeutic index | SIGNATURE R&D HOLDINGS, LLC | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069446-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | BCAT1, AADAT, TPI1 | PTGS1 3295/4885PTGS2 3832/4885MAPT 415/4885 |
| US-20100004481-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | BCAT1, AADAT, TPI1 | PTGS1 3295/4885PTGS2 3832/4885MAPT 415/4885 |
| US-20060287244-A1 | L-Threonine derivatives of high therapeutic index | BCAT1, AADAT, TPI1 | PTGS1 3295/4885PTGS2 3832/4885MAPT 415/4885 |
| US-20120289471-A1 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | IL4I1, SLC7A1, GOT1 | PTGS1 858/4885PTGS2 1068/4885MAPT 3272/4885 |
| US-20060241017-A1 | Novel compounds with high therapeutic index | IL4I1, SLC7A1, GOT1 | PTGS1 858/4885PTGS2 1068/4885MAPT 3272/4885 |
| US-20100069489-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | BCAT1, AADAT, TPI1 | PTGS1 3295/4885PTGS2 3832/4885MAPT 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.