Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 8/20 | 0.72 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.61 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29959902 | 0.93 | MAP4K4 (0.62) | MAP4K4MKNK1MKNK2CA1CA2 | |
| SCHEMBL77931 | 0.93 | MAP4K4 (0.62) | MAP4K4MKNK1MKNK2CA1CA2 | |
| Hydrochloric Acid SCHEMBL28021646 | 0.90 | MAP4K4 (0.60) | MAP4K4MKNK1MKNK2CA1CA2 | |
| Bromide SCHEMBL28799121 | 0.90 | MAP4K4 (0.60) | MAP4K4MKNK1MKNK2CA1CA2 | |
| Iodide SCHEMBL19056893 | 0.90 | MAP4K4 (0.60) | MAP4K4MKNK1MKNK2CA1CA2 | |
| Hydrochloric Acid SCHEMBL409480 | 0.90 | MAP4K4 (0.60) | MAP4K4MKNK1MKNK2CA1CA2 | |
| Hydrochloric Acid SCHEMBL3772040 | 0.90 | MAP4K4 (0.60) | MAP4K4MKNK1MKNK2CA1CA2 | |
| Nitrogen SCHEMBL27780715 | 0.88 | MAP4K4 (0.58) | MAP4K4MKNK1MKNK2CA1CA2 | |
| SCHEMBL1002578 | 0.87 | CA2 (0.67) | MAP4K4MKNK1MKNK2CA1CA2 | |
| SCHEMBL5952278 | 0.85 | RXRA (0.68) | MAP4K4MKNK1MKNK2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060014756-A1 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2006-01-19 | — | — | US | claimed |
| US-6897208-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | claimed |
| EP-1441725-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2004-08-04 | — | — | EP | claimed |
| US-20040048868-A1 | Benzimidazoles | AVENTISUB LLC | 2004-03-11 | — | — | US | claimed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | claimed |
| CN-115872947-B | Benzisothiazole benzamide compound or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2024-04-19 | — | — | CN | disclosed |
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-20120107273-A1 | NEW PIPERAZINE COMPOUND AND USE THEREOF AS A HCV POLYMERASE INHIBITOR | JAPAN TOBACCO INC. (JP) | 2012-05-03 | — | — | US | disclosed |
| EP-2298790-A1 | Daptomycin analogs as antibacterial agents | Cubist Pharmaceuticals, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| US-7592373-B2 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |
| US-7473671-B2 | Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2009-01-06 | — | — | US | disclosed |
| US-7473671-B2 | Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2009-01-06 | — | — | US | disclosed |
| US-7331920-B2 | Glycopeptide antibiotics, combinational libraries of glycopeptide antibiotics and methods of producing same | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2008-02-19 | — | — | US | disclosed |
| EP-1884520-A2 | Daptomycin analogs as antibacterial agents | Cubist Pharmaceuticals, Inc. (US) | 2008-02-06 | — | — | EP | disclosed |
| US-20060014756-A1 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2006-01-19 | — | — | US | disclosed |
| US-20050267093-A1 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-01 | — | — | US | disclosed |
| US-6897208-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | disclosed |
| EP-1441725-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2004-08-04 | — | — | EP | disclosed |
| US-20040048868-A1 | Benzimidazoles | AVENTISUB LLC | 2004-03-11 | — | — | US | disclosed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014756-A1 | Benzimidazoles | CDK9, BMX, SBK3 | MAP4K4 50/4885MKNK1 347/4885MKNK2 309/4885 |
| US-20040048868-A1 | Benzimidazoles | CDK9, BMX, CDKN1A | MAP4K4 61/4885MKNK1 408/4885MKNK2 430/4885 |
| US-20120107273-A1 | NEW PIPERAZINE COMPOUND AND USE THEREOF AS A HCV POLYMERASE INHIBITOR | POLR1C, POLR2E, POLR2H | MAP4K4 3208/4885MKNK1 3832/4885MKNK2 3783/4885 |
| US-20050267093-A1 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | MCHR1, MC4R, MCHR2 | MAP4K4 3543/4885MKNK1 2908/4885MKNK2 2390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.