Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Dioxane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL11296326 | 0.97 | TSHR (0.60) | TSHRTTR | |
| Dioxane SCHEMBL1072446 | 0.97 | TSHR (0.60) | TSHRTTR | |
| Dimethylformamide SCHEMBL10559930 | 0.94 | — | — | |
| Dioxane SCHEMBL28817546 | 0.91 | TSHR (0.53) | TSHRTTR | |
| Dimethylformamide SCHEMBL23322519 | 0.85 | TSHR (0.53) | TSHR | |
| Tetrahydrofuran SCHEMBL129722 | 0.85 | TSHR (0.53) | TSHR | |
| Dioxane SCHEMBL6550359 | 0.84 | TSHR (0.45) | TSHRTTR | |
| Tetrahydrofuran SCHEMBL28743802 | 0.82 | TSHR (0.50) | TSHR | |
| Dimethylformamide SCHEMBL1072443 | 0.82 | TSHR (0.50) | TSHR | |
| Dioxane SCHEMBL16719050 | 0.82 | TSHR (0.43) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773485-B1 | STABLE COMPOSITE MATERIAL COMPRISING SUPPORTED POROUS GELS | NATRIX SEPARATIONS INC (CA) | 2015-09-16 | — | — | EP | disclosed |
| EP-1758671-B9 | MEMBRANE STACKS | NATRIX SEPARATIONS INC (CA) | 2014-02-19 | — | — | EP | disclosed |
| US-8652849-B2 | Method for separating a substance from a fluid | NATRIX SEPARATIONS INC. (CA) | 2014-02-18 | — | — | US | disclosed |
| EP-1758671-B1 | MEMBRANE STACKS | NATRIX SEPARATIONS INC (CA) | 2013-09-04 | — | — | EP | disclosed |
| US-8383782-B2 | Composite materials comprising supported porous gels | NATRIX SEPARATIONS INC. (CA) | 2013-02-26 | — | — | US | disclosed |
| US-8367809-B2 | Composite materials comprising supported porous gels containing reactive functional groups | NATRIX SEPARATIONS INC. (CA) | 2013-02-05 | — | — | US | disclosed |
| US-8313651-B2 | Membrane stacks | NATRIX SEPARATIONS INC. (CA) | 2012-11-20 | — | — | US | disclosed |
| US-8211682-B2 | Composite material comprising supported porous gel containing functional groups and method of separating substances | NATRIX SEPARATIONS INC. (CA) | 2012-07-03 | — | — | US | disclosed |
| US-8206982-B2 | Composite materials comprising supported porous gels containing reactive functional groups | NATRIX SEPARATIONS INC. (CA) | 2012-06-26 | — | — | US | disclosed |
| US-8206958-B2 | Absorbing biological substances from liquid with supported porous gels containing binding sites | NATRIX SEPARATIONS INC. (CA) | 2012-06-26 | — | — | US | disclosed |
| US-20090032463-A1 | COMPOSITE MATERIALS COMPRISING SUPPORTED POROUS GELS | MERCK MILLIPORE LTD. (IE) | 2009-02-05 | — | — | US | disclosed |
| US-20090035552-A1 | COMPOSITE MATERIALS COMPRISING SUPPORTED POROUS GELS | MERCK MILLIPORE LTD. (IE) | 2009-02-05 | — | — | US | disclosed |
| US-20090029438-A1 | COMPOSITE MATERIALS COMPRISING SUPPORTED POROUS GELS | MERCK MILLIPORE LTD. (IE) | 2009-01-29 | — | — | US | disclosed |
| US-20090008328-A1 | Composite Materials Comprising Supported Porous Gels | NATRIX SEPARATIONS INC. (CA) | 2009-01-08 | — | — | US | disclosed |
| US-20080314831-A1 | Composite Materials Comprising Supported Porous Gels | NYSA MEMBRANCE TECHNOLOGIES INC. (CA) | 2008-12-25 | — | — | US | disclosed |
| US-20080312416-A1 | Composite Materials Comprising Supported Porous Gels | NYSA MEMBRANE TECHNOLOGIES INC. (CA) | 2008-12-18 | — | — | US | disclosed |
| US-20080264867-A1 | Stable Composite Material Comprising Supported Porous Gels | NYSA MEMBRANE TECHNOLOGIES INC. | 2008-10-30 | — | — | US | disclosed |
| US-20080017578-A1 | Membrane Stacks | MERCK MILLIPORE LTD. (IE) | 2008-01-24 | — | — | US | disclosed |
| US-7316919-B2 | Composite materials comprising supported porous gels | NYSA MEMBRANE TECHNOLOGIES (CA) | 2008-01-08 | — | — | US | disclosed |
| US-20040203149-A1 | Composite materials comprising supported porous gels | MERCK MILLIPORE LTD. (IE) | 2004-10-14 | — | — | US | disclosed |