Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29277059 | 0.86 | HSD11B1 (0.39) | TSHRMGLLNPSR1HSD11B1 | |
| SCHEMBL30015013 | 0.86 | TSHR (0.43) | TSHRMGLLNPSR1LIPGHSD11B1 | |
| SCHEMBL25920280 | 0.86 | PRKAG1 (0.40) | TSHRMGLLNPSR1LIPGHSD11B1 | |
| SCHEMBL27123175 | 0.86 | HTR1A (0.39) | TSHRNPSR1LIPGTNKSPARP1 | |
| SCHEMBL30014221 | 0.85 | ITGB3 (0.38) | TSHRMGLLNPSR1HSD11B1 | |
| SCHEMBL27125679 | 0.85 | ITGB3 (0.38) | TSHRMGLLNPSR1HSD11B1 | |
| SCHEMBL27147744 | 0.85 | NAMPT (0.36) | TSHRMGLLNAMPTHSD11B1 | |
| SCHEMBL29892557 | 0.85 | GPR119 (0.43) | — | |
| SCHEMBL28868792 | 0.85 | HSD11B1 (0.40) | TSHRMGLLNPSR1LIPGHSD11B1 | |
| SCHEMBL29201724 | 0.85 | HTR1A (0.38) | MGLLHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4328219-A1 | SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shanghai Leadingtac Pharmaceutical Co. Ltd. (CN) | 2024-02-28 | — | — | EP | disclosed |
| CN-115232111-A | SOS1 degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-115232108-A | SOS1 degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2022-10-25 | — | — | CN | disclosed |