Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trazodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 13/20 | 0.82 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.82 |
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.82 |
| ▸ | DRD2 | P14416 | 13/20 | 0.82 |
| ▸ | HTR1A | P08908 | 12/20 | 0.82 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.82 |
| ▸ | HRH1 | P35367 | 4/20 | 0.82 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.82 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.82 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.82 |
| ▸ | DRD1 | P21728 | 3/20 | 0.82 |
| ▸ | DRD4 | P21917 | 3/20 | 0.82 |
| ▸ | DRD3 | P35462 | 3/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.82 |
| ▸ | HPGD | P15428 | 2/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.82 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.82 |
| ▸ | HRH2 | P25021 | 2/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trazodone SCHEMBL8741340 | 0.91 | DRD2 (0.89) | DRD2HTR2AHTR1ASLC6A4ADRA1A | |
| Trazodone SCHEMBL29390760 | 0.91 | HTR1A (1.00) | DRD2HTR2AHTR1ASLC6A4ADRA1A | |
| Trazodone SCHEMBL28167 | 0.91 | HTR1A (1.00) | DRD2HTR2AHTR1ASLC6A4ADRA1A | |
| Trazodone SCHEMBL3402550 | 0.90 | KDM4E (1.00) | DRD2HTR2AHTR1ASLC6A4ADRA1A | |
| Trazodone SCHEMBL28226073 | 0.90 | HTR1A (0.98) | DRD2HTR2AHTR1ASLC6A4ADRA1A | |
| Trazodone SCHEMBL61754 | 0.90 | KDM4E (1.00) | DRD2HTR2AHTR1ASLC6A4ADRA1A | |
| Trazodone SCHEMBL29575935 | 0.90 | KDM4E (1.00) | DRD2HTR2AHTR1ASLC6A4ADRA1A | |
| Trazodone SCHEMBL120883 | 0.89 | HTR1A (0.96) | DRD2HTR2AHTR1ASLC6A4ADRA1A | |
| SCHEMBL11089944 | 0.89 | HTR1A (0.98) | DRD2HTR2AHTR1ASLC6A4ADRA1A | |
| Trazodone SCHEMBL27570399 | 0.88 | DRD2 (0.90) | DRD2HTR2AHTR1ASLC6A4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240173315-A1 | TRAZODONE ORAL SOLUTION | OWP Pharmaceuticals, Inc. | 2024-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240173315-A1 | TRAZODONE ORAL SOLUTION | HTR5A, TPH1, HTR4 | HTR2A 16/4885SLC6A4 22/4885HTR2C 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.