Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 3/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31467542 | 1.00 | RECQL (0.43) | RECQLNAAATSHRGLAHPGD | |
| SCHEMBL208567 | 1.00 | RECQL (0.43) | RECQLNAAATSHRGLAHPGD | |
| SCHEMBL138400 | 1.00 | RECQL (0.43) | RECQLNAAATSHRGLAHPGD | |
| SCHEMBL1171007 | 1.00 | RECQL (0.43) | RECQLNAAATSHRGLAHPGD | |
| Octane SCHEMBL7762184 | 1.00 | RECQL (0.43) | RECQLNAAATSHRGLAHPGD | |
| SCHEMBL8376551 | 1.00 | RECQL (0.43) | RECQLNAAATSHRGLAHPGD | |
| SCHEMBL6139132 | 1.00 | RECQL (0.43) | RECQLNAAATSHRGLAHPGD | |
| SCHEMBL4941649 | 1.00 | RECQL (0.43) | RECQLNAAATSHRGLAHPGD | |
| SCHEMBL401362 | 1.00 | RECQL (0.43) | RECQLNAAATSHRGLAHPGD | |
| SCHEMBL31196791 | 1.00 | RECQL (0.43) | RECQLNAAATSHRGLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632427-B1 | OPHTHALMIC COMPOSITIONS CONTAINING PROSTAGLANDINS | OMNIVISION GMBH (DE) | 2016-03-23 | — | — | EP | disclosed |
| EP-2632427-A1 | OPHTHALMIC COMPOSITION | Omnivision GmbH (DE) | 2013-09-04 | — | — | EP | disclosed |
| EP-2452669-A1 | Ophthalmic composition | Omnivision GmbH (DE) | 2012-05-16 | — | — | EP | disclosed |
| WO-2012055571-A1 | OPHTHALMIC COMPOSITION | OMNIVISION GMBH (DE) | 2012-05-03 | — | — | WO | disclosed |