Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP4 | Q13107 | 1/20 | 0.72 |
| ▸ | USP7 | Q93009 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PHGDH | O43175 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27312350 | 0.77 | USP4 (0.51) | USP4USP7LMNAPKMALDH1A1 | |
| SCHEMBL2736608 | 0.73 | ALDH1A1 (0.59) | LMNABRD4RAB9AALDH1A1MEN1 | |
| SCHEMBL13272883 | 0.73 | NPC1 (0.73) | BRD4RAB9AKMT2AHDAC2HDAC8 | |
| SCHEMBL8483573 | 0.72 | ERCC1 (0.59) | USP4USP7POLBHDAC2HDAC8 | |
| SCHEMBL9013681 | 0.72 | PKM (0.56) | USP4USP7LMNAPKMALDH1A1 | |
| SCHEMBL16403976 | 0.72 | LMNA (0.48) | LMNARAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL1149552 | 0.72 | HDAC3 (0.56) | LMNARAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL29190969 | 0.71 | USP4 (0.61) | USP4USP7KLKB1HDAC2HDAC8 | |
| SCHEMBL19753892 | 0.71 | LMNA (0.46) | LMNABRD4RAB9AALDH1A1MEN1 | |
| SCHEMBL6179001 | 0.70 | TDP1 (0.65) | LMNAPKMRAB9AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006956-A9 | DEUBIQUITINASE INHIBITORS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2024-04-11 | — | — | WO | disclosed |
| WO-2024006956-A2 | DEUBIQUITINASE INHIBITORS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2024-01-04 | — | — | WO | disclosed |