Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 9/20 | 0.39 |
| ▸ | MGAM | O43451 | 8/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 8/20 | 0.39 |
| ▸ | SI | P14410 | 8/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 8/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | F12 | P00748 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21904738 | 0.77 | DGAT1 (0.51) | DGAT1KMT2AHTTNPSR1MAPT | |
| SCHEMBL1971917 | 0.77 | DGAT1 (0.51) | DGAT1KMT2AHTTNPSR1MAPT | |
| SCHEMBL2732055 | 0.74 | DGAT1 (0.49) | DGAT1KMT2AHTTNPSR1MAPT | |
| SCHEMBL29031460 | 0.72 | DGAT1 (0.49) | DGAT1KMT2AHTTNPSR1MAPT | |
| SCHEMBL13519467 | 0.71 | CYP4Z1 (0.41) | DGAT1KMT2AHTTNPSR1MAPT | |
| SCHEMBL3893181 | 0.70 | DGAT1 (0.57) | DGAT1KMT2AHTTNPSR1MAPT | |
| SCHEMBL598226 | 0.69 | DGAT1 (0.49) | DGAT1KMT2AHTTNPSR1MAPT | |
| SCHEMBL30495312 | 0.69 | DGAT1 (0.47) | DGAT1KMT2AHTTNPSR1MAPT | |
| SCHEMBL21073734 | 0.69 | DGAT1 (0.51) | DGAT1KMT2AHTTNPSR1MAPT | |
| SCHEMBL16765694 | 0.68 | SIRT2 (0.45) | DGAT1KMT2AHTTNPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632915-B1 | BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INT (DE) | 2015-08-12 | — | — | EP | disclosed |
| US-8829200-B2 | Benzimidazole inhibitors of leukotriene production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-09 | — | — | US | disclosed |
| EP-2632915-A1 | BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION | Boehringer Ingelheim International GmbH (DE) | 2013-09-04 | — | — | EP | disclosed |
| US-20120277226-A1 | BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-01 | — | — | US | disclosed |
| WO-2012058254-A1 | BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277226-A1 | BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION | LTB4R, LTB4R2, LTC4S | DGAT1 2184/4885KMT2A 4028/4885HTT 4216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.