Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11741518 | 0.79 | HSD11B1 (0.36) | HSD11B1MMEPKMKMT2AAKR1B1 | |
| SCHEMBL159193 | 0.79 | HSD11B1 (0.36) | HSD11B1MMEPKMKMT2AMAOA | |
| SCHEMBL4679449 | 0.79 | HSD11B1 (0.36) | HSD11B1MMEAVPR2OXTRAVPR1A | |
| SCHEMBL10587681 | 0.79 | LMNA (0.38) | HSD11B1MAOAMAOB | |
| SCHEMBL6059687 | 0.76 | HSD11B1 (0.33) | HSD11B1MME | |
| SCHEMBL7529245 | 0.75 | CA1 (0.35) | MMEMAOAMAOBHDAC9 | |
| SCHEMBL8068895 | 0.73 | MAOA (0.35) | MMEMAOAMAOBHDAC9 | |
| SCHEMBL258234 | 0.71 | PARP1 (0.36) | MAOB | |
| SCHEMBL31520302 | 0.71 | PARP1 (0.36) | MAOB | |
| SCHEMBL28845170 | 0.71 | ALDH1A1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1007727-B | PROCESS FOR THE PREPARATION OF TETRAHYDRONAPHTALINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1990-04-25 | — | — | CN | disclosed |
| CN-85107496-A | The method for preparing tetrahydronaphthalenderivatives derivatives | — | 1986-07-23 | — | — | CN | disclosed |