Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6803287 | 1.00 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2PLK1THRA | |
| SCHEMBL6803238 | 0.81 | ALDH1A1 (0.47) | NPC1RAB9ASMN1; SMN2PLK1THRA | |
| SCHEMBL6802684 | 0.74 | CA2 (0.42) | NPC1RAB9ASMN1; SMN2PLK1THRA | |
| SCHEMBL7290900 | 0.72 | ALDH1A1 (0.54) | NPC1RAB9ASMN1; SMN2PLK1THRA | |
| SCHEMBL964123 | 0.71 | SPHK1 (0.49) | THRATHRBALDH1A1SPHK1S1PR2 | |
| SCHEMBL6803279 | 0.71 | SIGMAR1 (0.45) | NPC1RAB9ASMN1; SMN2PLK1THRA | |
| SCHEMBL8553953 | 0.71 | SIGMAR1 (0.45) | NPC1RAB9ASMN1; SMN2PLK1THRA | |
| SCHEMBL6803409 | 0.71 | ALDH1A1 (0.53) | NPC1RAB9ASMN1; SMN2PLK1ALDH1A1 | |
| SCHEMBL9475225 | 0.69 | ALOX5 (0.66) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL27502124 | 0.69 | CA2 (0.48) | NPC1RAB9ASMN1; SMN2PLK1THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1056602-C | Esters and amides as PLA2 inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 2000-09-20 | — | — | CN | disclosed |
| CN-1197450-A | Esters and amides as phospholipase A2 inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-10-28 | — | — | CN | disclosed |