Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRAT | O95237 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.67 |
| ▸ | GJA1 | P17302 | 1/20 | 0.62 |
| ▸ | GJB2 | P29033 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paromamine SCHEMBL15251517 | 1.00 | LRAT (0.79) | LRATLMNAKDM4EALOX15TSHR | |
| Paromamine SCHEMBL18616648 | 1.00 | LRAT (0.79) | LRATLMNAKDM4EALOX15TSHR | |
| Paromamine SCHEMBL14495298 | 1.00 | LRAT (0.79) | LRATLMNAKDM4EALOX15TSHR | |
| Paromamine SCHEMBL22476648 | 1.00 | LRAT (0.79) | LRATLMNAKDM4EALOX15TSHR | |
| Paromamine SCHEMBL13873360 | 1.00 | LRAT (0.79) | LRATLMNAKDM4EALOX15TSHR | |
| Paromamine SCHEMBL12168155 | 1.00 | LRAT (0.79) | LRATLMNAKDM4EALOX15TSHR | |
| Paromamine SCHEMBL8812240 | 1.00 | LRAT (0.79) | LRATLMNAKDM4EALOX15TSHR | |
| Paromamine SCHEMBL30804048 | 0.93 | BLM (0.72) | LRATLMNAKDM4EALOX15TSHR | |
| SCHEMBL22047136 | 0.91 | LRAT (0.66) | LRATLMNAKDM4EALOX15TSHR | |
| SCHEMBL2538392 | 0.91 | ALOX15 (0.81) | LRATLMNAKDM4EALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11786539-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | ELOXX PHARMACEUTICALS LTD. (IL) | 2023-10-17 | — | — | US | disclosed |
| US-20230181612-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | ELOXX PHARMACEUTICALS LTD. (IL) | 2023-06-15 | — | — | US | disclosed |
| US-11673907-B2 | Modular synthesis of aminoglycosides | REVAGENIX, INC. (US) | 2023-06-13 | — | — | US | disclosed |
| US-20230167148-A1 | MODULAR SYNTHESIS OF AMINOGLYCOSIDES | REVAGENIX, INC. | 2023-06-01 | — | — | US | disclosed |
| US-20220411456-A1 | MODULAR SYNTHESIS OF AMINOGLYCOSIDES | REVAGENIX, INC. (US) | 2022-12-29 | — | — | US | disclosed |
| US-11306115-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | ELOXX PHARMACEUTICALS LTD. (IL) | 2022-04-19 | — | — | US | disclosed |
| US-20220033428-A1 | LARGE SCALE PREPARATION OF PSEUDO-TRISACCHARIDE AMINOGLYCOSIDES AND OF INTERMEDIATES THEREOF | ELOXX PHARMACEUTICALS LTD. (IL) | 2022-02-03 | — | — | US | disclosed |
| US-11136345-B2 | Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof | ELOXX PHARMACEUTICALS LTD. (IL) | 2021-10-05 | — | — | US | disclosed |
| US-20210220380-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | ELOXX PHARMACEUTICALS LTD. (IL) | 2021-07-22 | — | — | US | disclosed |
| US-10973839-B2 | Aminoglycosides and uses thereof in treating genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2021-04-13 | — | — | US | disclosed |
| US-9616079-B2 | Aminoglycosides and uses thereof in treating genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2017-04-11 | — | — | US | disclosed |
| WO-2017037717-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | ELOXX PHARMACEUTICALS LTD. (IL) | 2017-03-09 | — | — | WO | disclosed |
| US-8729035-B2 | Synthesis of novel neamine derivatives and use thereof as antibacterial agents | UNIVERSITE JOSEPH FOURIER (FR) | 2014-05-20 | — | — | US | disclosed |
| US-8729035-B2 | Synthesis of novel neamine derivatives and use thereof as antibacterial agents | UNIVERSITE JOSEPH FOURIER (FR) | 2014-05-20 | — | — | US | disclosed |
| US-8088626-B2 | Chiral selectors for separating enantiomers of a compound | University Joseph Fourier (Grenoble 1) (FR) | 2012-01-03 | — | — | US | disclosed |
| US-20100311680-A1 | SYNTHESIS OF NOVEL NEAMINE DERIVATIVES AND USE THEREOF AS ANTIBACTERIAL AGENTS | UNIVERSITE JOSEPH FOURIER (FR) | 2010-12-09 | — | — | US | disclosed |
| US-20100311680-A1 | SYNTHESIS OF NOVEL NEAMINE DERIVATIVES AND USE THEREOF AS ANTIBACTERIAL AGENTS | UNIVERSITE JOSEPH FOURIER (FR) | 2010-12-09 | — | — | US | disclosed |
| US-20100144045-A1 | CHIRAL SELECTORS FOR SEPARATING ENANTIOMERS OF A COMPOUND | UNIVERISTE JOSEPH FOURIER (GRENOBLE 1) (FR) | 2010-06-10 | — | — | US | disclosed |
| WO-2009095588-A2 | SYNTHESIS OF NOVEL NEAMINE DERIVATIVES AND USE THEREOF AS ANTIBACTERIAL AGENTS | UNIVERSITE JOSEPH FOURIER (FR) | 2009-08-06 | — | — | WO | disclosed |
| WO-2008132340-A2 | CHIRAL SELECTORS FOR SEPARATING ENANTIOMERS OF A COMPOUND | UNIVERSITE JOSEPH FOURIER (GRENOBLE 1) (FR) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11673907-B2 | Modular synthesis of aminoglycosides | MRPL21, COASY, AARS1 | LRAT 945/4885LMNA 2679/4885KDM4E 3762/4885 |
| US-20100144045-A1 | CHIRAL SELECTORS FOR SEPARATING ENANTIOMERS OF A COMPOUND | CD2, CD22, CA2 | LRAT 2404/4885LMNA 4394/4885KDM4E 2950/4885 |
| US-20210220380-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | UPF1, UGGT1, ARSA | LRAT 2094/4885LMNA 2467/4885KDM4E 3335/4885 |
| US-11306115-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | UPF1, IDUA, UGGT1 | LRAT 2020/4885LMNA 2417/4885KDM4E 3531/4885 |
| US-11786539-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | UPF1, UGGT1, ARSA | LRAT 2094/4885LMNA 2467/4885KDM4E 3335/4885 |
| US-20100311680-A1 | SYNTHESIS OF NOVEL NEAMINE DERIVATIVES AND USE THEREOF AS ANTIBACTERIAL AGENTS | HRH3, HRH4, H1-4 | LRAT 1193/4885LMNA 4185/4885KDM4E 2234/4885 |
| US-11136345-B2 | Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof | OSTC, TREH, GPI | LRAT 923/4885LMNA 3303/4885KDM4E 4164/4885 |
| US-20220033428-A1 | LARGE SCALE PREPARATION OF PSEUDO-TRISACCHARIDE AMINOGLYCOSIDES AND OF INTERMEDIATES THEREOF | OSTC, TREH, GPI | LRAT 923/4885LMNA 3303/4885KDM4E 4164/4885 |
| US-20230167148-A1 | MODULAR SYNTHESIS OF AMINOGLYCOSIDES | MRPL21, COASY, AARS1 | LRAT 945/4885LMNA 2679/4885KDM4E 3762/4885 |
| US-10973839-B2 | Aminoglycosides and uses thereof in treating genetic disorders | AARS1, GARS1, UPF1 | LRAT 1724/4885LMNA 2154/4885KDM4E 3261/4885 |
| US-20220411456-A1 | MODULAR SYNTHESIS OF AMINOGLYCOSIDES | MRPL21, COASY, AARS1 | LRAT 945/4885LMNA 2679/4885KDM4E 3762/4885 |
| US-20230181612-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | UPF1, NSUN3, AARS1 | LRAT 2253/4885LMNA 768/4885KDM4E 3817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.