Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 2/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21484499 | 0.83 | HRH3 (0.38) | MAPTCREBBPALDH1A1 | |
| SCHEMBL30500455 | 0.79 | KDM5B (0.38) | KDM5BHSD17B10MAPTKDM4ECREBBP | |
| SCHEMBL24664733 | 0.79 | SORT1 (0.33) | MAPTCREBBPALDH1A1BMPR1BBMPR1A | |
| SCHEMBL22757227 | 0.77 | BRD4 (0.44) | HSD17B10KDM4ECREBBPALDH1A1CYP1A2 | |
| SCHEMBL3986304 | 0.75 | ALDH1A1 (0.38) | HSD17B10MAPTKDM4ECREBBPPDE1A | |
| SCHEMBL9797818 | 0.67 | NOS2 (0.38) | KDM5BKDM4EGABRA2GABRB2BACE1 | |
| SCHEMBL27369130 | 0.65 | MGLL (0.43) | MAPTKDM4ECREBBPALDH1A1 | |
| SCHEMBL10566 | 0.64 | CPB2 (0.41) | CYP2C19CYP2C9 | |
| SCHEMBL294175 | 0.63 | KDM4E (0.32) | KDM4E | |
| SCHEMBL299637 | 0.63 | NOS2 (0.36) | HSD17B10KDM4EALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059665-A1 | DIMERIC COMPOUNDS AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2024-03-21 | — | — | WO | disclosed |