Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28436430 | 0.87 | MAPT (0.40) | ALDH1A1MAPTHTTTDP1TERT | |
| SCHEMBL28433432 | 0.84 | MAPT (0.38) | ALDH1A1MAPTLMNAHTTKMT2A | |
| SCHEMBL28523211 | 0.84 | KMT2A (0.47) | ALDH1A1MAPTKMT2AMEN1TERT | |
| SCHEMBL29018666 | 0.82 | NR3C2 (0.41) | ALDH1A1MAPTHTTSMN1; SMN2POLB | |
| SCHEMBL13423067 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNAHTTKMT2A | |
| SCHEMBL13423460 | 0.75 | ALDH1A1 (0.40) | ALDH1A1MAPTLMNAHTTKMT2A | |
| SCHEMBL28776773 | 0.72 | TERT (0.32) | ALDH1A1MAPTHTTTERTSMN1; SMN2 | |
| SCHEMBL10594147 | 0.70 | MEN1 (0.41) | ALDH1A1MAPTLMNAHTTKMT2A | |
| SCHEMBL28897005 | 0.70 | HSD17B10 (0.41) | ALDH1A1MAPTLMNAHTTKMT2A | |
| SCHEMBL16740590 | 0.70 | PRKCZ (0.69) | LMNAPRKCZPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128435-A | Pyrazolone compounds as metabotropic glutamate receptor agonists for the treatment of neurological and psychiatric disorders | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |
| CN-1066138-C | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GMBH (DE) | 2001-05-23 | — | — | CN | disclosed |
| CN-1141291-A | 4-(Arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GMBH (DE) | 1997-01-29 | — | — | CN | disclosed |