Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27546919 | 0.84 | HTR2C (0.42) | DRD2DRD3NCF1HTR1AHTR2A | |
| SCHEMBL27546910 | 0.78 | ADRA2C (0.37) | ADRA2CDRD2DRD3NCF1DRD4 | |
| SCHEMBL27567085 | 0.76 | ADRA2C (0.36) | ADRA2CDRD2NCF1HTR2A | |
| SCHEMBL16308828 | 0.76 | ACHE (0.39) | DRD2HTR1A | |
| SCHEMBL2856023 | 0.76 | ACHE (0.39) | DRD2HTR1A | |
| SCHEMBL27546915 | 0.74 | DRD2 (0.41) | ADRA2CDRD2DRD3NCF1DRD4 | |
| SCHEMBL7470810 | 0.73 | CXCR4 (0.44) | CXCR4 | |
| SCHEMBL7246237 | 0.73 | NCF1 (0.36) | ADRA2CDRD2DRD3NCF1DRD4 | |
| SCHEMBL7025288 | 0.72 | DRD3 (0.47) | ADRA2CDRD2DRD3CXCR4 | |
| SCHEMBL4788557 | 0.72 | DRD3 (0.47) | ADRA2CDRD2DRD3CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1073101-C | Substituted 1,2,3, 4-tetrahydronaphthalene derivatives | ASTRA AB (SE) | 2001-10-17 | — | — | CN | disclosed |
| CN-1278727-A | Monoamine oxidase inhibitors and h 5-ht1BCombinations of antagonists or partial agonists | ASTRAZENECA AB (SE) | 2001-01-03 | — | — | CN | disclosed |
| CN-1219170-A | Substituted 1,2,3, 4-tetrahydronaphthalene derivatives | ASTRA AB (SE) | 1999-06-09 | — | — | CN | disclosed |