Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | LAP3 | P28838 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231156 | 1.00 | CA12 (0.45) | CA12CA2CA9CA1CA4 | |
| SCHEMBL18025354 | 0.93 | CA12 (0.44) | CA12CA2CA9CA1CA4 | |
| SCHEMBL17166629 | 0.90 | CA12 (0.44) | CA12CA2CA9CA1CA4 | |
| SCHEMBL16441206 | 0.90 | CA12 (0.44) | CA12CA2CA9CA1CA4 | |
| SCHEMBL16607619 | 0.89 | ITGB3 (0.53) | CA12CA2CA9CA1CA4 | |
| SCHEMBL10001634 | 0.89 | LTA4H (0.47) | CA12CA2CA9CA1CA4 | |
| SCHEMBL20215813 | 0.89 | LTA4H (0.47) | CA12CA2CA9CA1CA4 | |
| SCHEMBL10001633 | 0.88 | CA12 (0.47) | CA12CA2CA9CA1CA4 | |
| SCHEMBL19881530 | 0.88 | ACACB (0.50) | ITGB3ITGA2BACACB | |
| Hydrochloric Acid SCHEMBL5755082 | 0.87 | LTA4H (0.46) | CA12CA2CA9CA1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11572384-B2 | Unusual substrates of tubulin tyrosine ligase | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2023-02-07 | — | — | US | disclosed |
| CN-112739823-A | Pyrrolysinyl-tRNA synthetases | 国立研究开发法人理化学研究所 | 2021-04-30 | — | — | CN | disclosed |
| US-20210040145-A1 | MEANS AND METHODS FOR SITE-SPECIFIC FUNCTIONALIZATION OF POLYPEPTIDES | UNIV MUENCHEN LUDWIG MAXIMILIANS (DE) | 2021-02-11 | — | — | US | disclosed |
| EP-3733687-A1 | MEANS AND METHODS FOR SITE-SPECIFIC FUNCTIONALIZATION OF POLYPEPTIDES | Ludwig-Maximilians-Universität München (DE) | 2020-11-04 | — | — | EP | disclosed |
| US-10745437-B2 | Means and methods for site-specific functionalization of polypeptides | LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) | 2020-08-18 | — | — | US | disclosed |
| US-20190144493-A1 | UNUSUAL SUBSTRATES OF TUBULIN TYROSINE LIGASE | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2019-05-16 | — | — | US | disclosed |
| US-10208084-B2 | Means and methods for site-specific functionalization of polypeptides | LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) | 2019-02-19 | — | — | US | disclosed |
| US-20170349625-A1 | MEANS AND METHODS FOR SITE-SPECIFIC FUNCTIONALIZATION OF POLYPEPTIDES | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2017-12-07 | — | — | US | disclosed |
| US-20170349625-A1 | MEANS AND METHODS FOR SITE-SPECIFIC FUNCTIONALIZATION OF POLYPEPTIDES | FORSCHUNGSVERBUND BERLIN E.V. (DE) | 2017-12-07 | — | — | US | disclosed |
| US-9797908-B2 | Unnatural reactive amino acid genetic code additions | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-10-24 | — | — | US | disclosed |
| US-20100160618-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-06-24 | — | — | US | disclosed |
| US-7718410-B2 | Orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases incorporate para-propargyloxyphenylalanine into proteins produced in E. coli | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-18 | — | — | US | disclosed |
| US-7625717-B2 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-12-01 | — | — | US | disclosed |
| US-7618775-B2 | Cells comprise orthogonal aminoacyl-tRNA synthetase and p-acetyl-L-phenylalanine; site-directed mutagenesis; kits | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-11-17 | — | — | US | disclosed |
| US-7608423-B2 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-10-27 | — | — | US | disclosed |
| US-20080227195-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-18 | — | — | US | disclosed |
| US-20080220472-A1 | Orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases incorporate para-propargyloxyphenylalanine into proteins produced in E. coli | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-11 | — | — | US | disclosed |
| US-20080176277-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-07-24 | — | — | US | disclosed |
| US-20070166791-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-19 | — | — | US | disclosed |
| US-20070154952-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349625-A1 | MEANS AND METHODS FOR SITE-SPECIFIC FUNCTIONALIZATION OF POLYPEPTIDES | PTMS, DNPEP, LNPEP | CA12 1337/4885CA2 4221/4885CA9 3514/4885 |
| US-20070154952-A1 | Expanding the eukaryotic genetic code | NSUN3, AARS1, TRMT1 | CA12 4344/4885CA2 3832/4885CA9 4064/4885 |
| US-11572384-B2 | Unusual substrates of tubulin tyrosine ligase | TTL, TUBA1C, TUBB6 | CA12 3846/4885CA2 4291/4885CA9 4469/4885 |
| US-20210040145-A1 | MEANS AND METHODS FOR SITE-SPECIFIC FUNCTIONALIZATION OF POLYPEPTIDES | PTMS, DNPEP, LNPEP | CA12 1337/4885CA2 4221/4885CA9 3514/4885 |
| US-10208084-B2 | Means and methods for site-specific functionalization of polypeptides | PTMS, DNPEP, LNPEP | CA12 1337/4885CA2 4221/4885CA9 3514/4885 |
| US-20190144493-A1 | UNUSUAL SUBSTRATES OF TUBULIN TYROSINE LIGASE | TTL, TUBA1C, TUBB6 | CA12 3846/4885CA2 4291/4885CA9 4469/4885 |
| US-20100160618-A1 | Expanding the eukaryotic genetic code | NSUN3, AARS1, TRMT1 | CA12 4344/4885CA2 3832/4885CA9 4064/4885 |
| US-10745437-B2 | Means and methods for site-specific functionalization of polypeptides | PTMS, DNPEP, LNPEP | CA12 1337/4885CA2 4221/4885CA9 3514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.