Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | GLP1R | P43220 | 19/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL27432308 | 0.91 | KEAP1 (0.43) | KEAP1GLP1R | |
| Tryptophan SCHEMBL27493966 | 0.90 | KEAP1 (0.42) | KEAP1GLP1R | |
| Tryptophan SCHEMBL27546659 | 0.89 | KEAP1 (0.41) | KEAP1GLP1R | |
| Tryptophan SCHEMBL27501630 | 0.87 | IL23R (0.45) | GLP1R | |
| Dl-Tryptophan SCHEMBL27789301 | 0.87 | CTSC (0.41) | KEAP1 | |
| Tryptophan SCHEMBL27389650 | 0.86 | TUBB4A (0.44) | GLP1R | |
| Tyrosine SCHEMBL27506997 | 0.83 | NPY4R (0.39) | KEAP1GLP1R | |
| Tryptophan SCHEMBL27677376 | 0.83 | TLR2 (0.37) | KEAP1GLP1R | |
| Tryptophan SCHEMBL27503845 | 0.82 | GHSR (0.39) | GLP1R | |
| Tryptophan SCHEMBL27376884 | 0.81 | PTH1R (0.42) | KEAP1GLP1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1123113-A | Super-concentrated nutrition with special effect for reducing weight | GUO XIANGSI (CN) | 1996-05-29 | — | — | CN | disclosed |