SCHEMBL27434591

SCHEMBL27434591

COc1cc(F)c2c(c1)OCC(=O)N2C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.36
GABRG2 P18507 1/20 0.35
GABRB3 P28472 1/20 0.35
GABRA5 P31644 1/20 0.35
PKM P14618 2/20 0.35
PKLR P30613 1/20 0.35
MAOB P27338 2/20 0.34
ALOX5 P09917 2/20 0.34
CBX7 O95931 1/20 0.34
CDYL2 Q8N8U2 1/20 0.34
CDYL Q9Y232 1/20 0.34
CDY1; CDY1B Q9Y6F8 1/20 0.34
ALDH1A1 P00352 3/20 0.33
KDM4E B2RXH2 3/20 0.33
GAA P10253 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
NPC1 O15118 2/20 0.33
MAPT P10636 2/20 0.33
RAB9A P51151 2/20 0.33
HTR1A P08908 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30336272 0.79 PDE3B (0.35) GABRG2GABRB3GABRA5PKMALOX5
SCHEMBL29209037 0.79 PDE3B (0.35) GABRG2GABRB3GABRA5PKMALOX5
SCHEMBL6530748 0.79 CYP11B2 (0.34) GABRG2GABRB3GABRA5ALOX5CYP11B1
SCHEMBL6526548 0.74 TERT (0.41) L3MBTL1GABRG2GABRB3GABRA5ALOX5
SCHEMBL27434592 0.74 HTR1A (0.36) L3MBTL1MAOBALOX5KDM4EGAA
SCHEMBL1494252 0.73 LMNA (0.52) L3MBTL1GABRG2GABRB3GABRA5ALOX5
SCHEMBL30336343 0.72 TERT (0.41) L3MBTL1MAOBHTR1AHTR2CCYP11B1
SCHEMBL31180349 0.71 ROCK1 (0.38) ALOX5CYP11B1CYP11B2
SCHEMBL30954100 0.71 HTR1A (0.45) GABRG2GABRB3GABRA5ALOX5KDM4E
SCHEMBL27433237 0.71 HTR1A (0.45) GABRG2GABRB3GABRA5ALOX5KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4630412-A1 COMPOUNDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD Pharma A/S (DK) 2025-10-15 EP disclosed
WO-2024121130-A1 COMPOUNDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD PHARMA A/S (DK) 2024-06-13 WO disclosed
WO-2024121130-A1 COMPOUNDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD PHARMA A/S (DK) 2024-06-13 WO disclosed