Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | CDK4 | P11802 | 4/20 | 0.57 |
| ▸ | CCND1 | P24385 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30074152 | 1.00 | KMT2A (0.71) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL27602860 | 0.85 | KMT2A (0.65) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL1598786 | 0.83 | KMT2A (1.00) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL29420405 | 0.83 | KMT2A (1.00) | KMT2AMAPK1CDK4CCND1LMNA | |
| Acetic Acid SCHEMBL27760597 | 0.83 | KMT2A (0.68) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL12881191 | 0.82 | LMNA (0.71) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL15262402 | 0.82 | KMT2A (0.66) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL15262406 | 0.82 | KMT2A (0.66) | KMT2AMAPK1CDK4CCND1LMNA | |
| Hydrochloric Acid SCHEMBL25303352 | 0.81 | KMT2A (0.96) | KMT2AMAPK1CDK4CCND1LMNA | |
| SCHEMBL1519806 | 0.81 | KMT2A (0.71) | KMT2AMAPK1CDK4CCND1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691959-B2 | Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds | AVEXXIN AS (NO) | 2023-07-04 | — | — | US | disclosed |
| US-20230121337-A1 | CDK2 INHIBITORS AND METHODS OF USING THE SAME | CEDILLA THERAPEUTICS, INC. | 2023-04-20 | — | — | US | disclosed |
| US-11034666-B2 | Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds | AVEXXIN AS (NO) | 2021-06-15 | — | — | US | disclosed |
| US-20200299256-A1 | ANTI-INFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS | AVEXXIN AS (NO) | 2020-09-24 | — | — | US | disclosed |
| EP-3677259-A1 | USE OF ARACHIDONYL TRIFLUOROMETHYL KETONE | Mosaiques Diagnostics And Therapeutics AG (DE) | 2020-07-08 | — | — | EP | disclosed |
| CN-110128370-A | Anti-inflammatory and antitumor 2- oxothiazoiium class and 2- oxo thiophenes | 埃维克辛公司 | 2019-08-16 | — | — | CN | disclosed |
| EP-2951164-B1 | ANTIINFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES COMPOUNDS | AVEXXIN AS (NO) | 2019-06-05 | — | — | EP | disclosed |
| CN-105102438-B | Anti-inflammatory and anti-tumor 2-oxothiazoles and 2-oxothiophenes | 埃维克辛公司 | 2019-04-30 | — | — | CN | disclosed |
| US-10259801-B2 | Anti-inflammatory and antitumor 2-oxothiazoles ABD 2-oxothiophenes compounds | AVEXXIN AS (NO) | 2019-04-16 | — | — | US | disclosed |
| US-20180105507-A1 | ANTIIFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES ABD 2-OXOTHIOPHENES COMPOUNDS | AVEXXIN AS (NO) | 2018-04-19 | — | — | US | disclosed |
| US-20150376161-A1 | ANTIIFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES ABD 2-OXOTHIOPHENES COMPOUNDS | AVEXXIN AS (NO) | 2015-12-31 | — | — | US | disclosed |
| EP-2951164-A1 | ANTIINFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS | Avexxin AS (NO) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014118195-A1 | ANTIINFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS | AVEXXIN AS (NO) | 2014-08-07 | — | — | WO | disclosed |
| US-5132319-A | Antiasthmatic, antiinflammatory, antiallergen and cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1992-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376161-A1 | ANTIIFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES ABD 2-OXOTHIOPHENES COMPOUNDS | FOXO1, FOXO3, BCOR | KMT2A 3942/4885MAPK1 2093/4885CDK4 3141/4885 |
| US-20230121337-A1 | CDK2 INHIBITORS AND METHODS OF USING THE SAME | CDK2, CDK20, CDK2AP2 | KMT2A 1017/4885MAPK1 531/4885CDK4 12/4885 |
| US-11034666-B2 | Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds | CASP1, OXER1, IL1B | KMT2A 2998/4885MAPK1 977/4885CDK4 1532/4885 |
| US-20180105507-A1 | ANTIIFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES ABD 2-OXOTHIOPHENES COMPOUNDS | FOXO1, FOXO3, BCOR | KMT2A 3942/4885MAPK1 2093/4885CDK4 3141/4885 |
| US-10259801-B2 | Anti-inflammatory and antitumor 2-oxothiazoles ABD 2-oxothiophenes compounds | OXER1, CCL2, IL6 | KMT2A 3269/4885MAPK1 1777/4885CDK4 2763/4885 |
| US-20200299256-A1 | ANTI-INFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS | CASP1, OXER1, IL1B | KMT2A 2945/4885MAPK1 992/4885CDK4 1487/4885 |
| US-11691959-B2 | Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds | CASP1, IL1B, OXER1 | KMT2A 3107/4885MAPK1 879/4885CDK4 1660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.