SCHEMBL2748306

SCHEMBL2748306

C=C(c1ccc(C(C)(C)C)cc1)c1cccc(C(=C)c2ccc(C(C)(C)C)cc2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNK9 Q9NPC2 1/20 0.47
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
KCNK3 O14649 1/20 0.43
HDAC1 Q13547 1/20 0.42
NR1H4 Q96RI1 1/20 0.42
LMNA P02545 1/20 0.41
TYR P14679 1/20 0.41
SRD5A2 P31213 1/20 0.41
TP53 P04637 1/20 0.41
ACHE P22303 3/20 0.41
SIRT1 Q96EB6 1/20 0.41
HDAC8 Q9BY41 2/20 0.40
HDAC6 Q9UBN7 2/20 0.40
MAPT P10636 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
DHODH Q02127 1/20 0.39
NR4A1 P22736 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19160290 0.91 KCNK9 (0.42) KCNK9MEN1KMT2ASMN1; SMN2KCNK3
SCHEMBL6547689 0.88 MEN1 (0.53) KCNK9MEN1KMT2AHDAC1NR1H4
SCHEMBL28160104 0.87 LMNA (0.52) MEN1KMT2ASMN1; SMN2HDAC1NR1H4
SCHEMBL20101606 0.84 SIRT1 (0.55) KCNK9MEN1KMT2ASMN1; SMN2LMNA
SCHEMBL2749446 0.77 MEN1 (0.45) MEN1KMT2ASMN1; SMN2LMNAACHE
SCHEMBL4190159 0.76 KCNK9 (0.56) KCNK9MEN1KMT2ASMN1; SMN2KCNK3
SCHEMBL814654 0.75 MEN1 (0.52) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL739381 0.75 ESR1 (0.54) KCNK9MEN1KMT2ASMN1; SMN2MAPT
Lithium SCHEMBL31099176 0.75 MEN1 (0.44) MEN1KMT2ASMN1; SMN2LMNAMAPT
SCHEMBL13350459 0.74 POLB (0.38) SMN1; SMN2HDAC1SRD5A2TP53SIRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10858377-B2 Multivinylaminosilanes as branching agents for functionalized elastomeric polymers TRINSEO EUROPE GMBH (CH) 2020-12-08 US disclosed
US-20200055881-A1 MULTIVINYLAMINOSILANES AS BRANCHING AGENTS FOR FUNCTIONALIZED ELASTOMERIC POLYMERS TRINSEO EUROPE GMBH (CH) 2020-02-20 US disclosed
EP-3059240-B1 Multivinylaminosilanes as branching agents for functionalized elastomeric polymers TRINSEO EUROPE GMBH (CH) 2019-10-30 EP disclosed
US-20180030070-A1 Multivinylaminosilanes as Branching Agents for Functionalized Elastomeric Polymers TRINSEO EUROPE GMBH (CH) 2018-02-01 US disclosed
WO-2016131590-A1 MULTIVINYLAMINOSILANES AS BRANCHING AGENTS FOR FUNCTIONALIZED ELASTOMERIC POLYMERS TRINSEO EUROPE GMBH (CH) 2016-08-25 WO disclosed
EP-3059240-A1 Multivinylaminosilanes as branching agents for functionalized elastomeric polymers Trinseo Europe GmbH (CH) 2016-08-24 EP disclosed
US-8178641-B2 Amino group-containing conjugated diene polymer and method for producing the same, and block copolymer and method for producing the same JSR CORPORATION (JP) 2012-05-15 US disclosed
US-20100267918-A1 AMINO GROUP-CONTAINING CONJUGATED DIENE POLYMER AND METHOD FOR PRODUCING THE SAME, AND BLOCK COPOLYMER AND METHOD FOR PRODUCING THE SAME JSR CORPORATION (JP) 2010-10-21 US disclosed
US-5180799-A Organolithium-Organoaluminum Catalyst IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200055881-A1 MULTIVINYLAMINOSILANES AS BRANCHING AGENTS FOR FUNCTIONALIZED ELASTOMERIC POLYMERS PRUNE1, GNE, TERB1 KCNK9 4091/4885MEN1 2494/4885KMT2A 2571/4885
US-20180030070-A1 Multivinylaminosilanes as Branching Agents for Functionalized Elastomeric Polymers GMNN, GNE, MSN KCNK9 3897/4885MEN1 1962/4885KMT2A 2368/4885
US-10858377-B2 Multivinylaminosilanes as branching agents for functionalized elastomeric polymers GMNN, GNE, MSN KCNK9 3897/4885MEN1 1962/4885KMT2A 2368/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.