SCHEMBL2759656

SCHEMBL2759656

N#Cc1ccc(N(c2ccc(C#N)cc2)c2ccc(N=O)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.47
TSHR P16473 2/20 0.47
HSD17B10 Q99714 2/20 0.47
TP53 P04637 1/20 0.47
MAPK1 P28482 1/20 0.47
HIF1A Q16665 1/20 0.47
KDM4E B2RXH2 3/20 0.41
GAA P10253 2/20 0.41
MEN1 O00255 2/20 0.41
MAPT P10636 2/20 0.41
HPGD P15428 2/20 0.41
KMT2A Q03164 2/20 0.41
USP2 O75604 1/20 0.41
NOS3 P29474 2/20 0.41
NOS1 P29475 2/20 0.41
LMNA P02545 2/20 0.39
CYP1B1 Q16678 1/20 0.39
CYP2A6 P11509 2/20 0.38
ENPP2 Q13822 1/20 0.38
CA2 P00918 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23992537 0.93 TSHR (0.43) ALDH1A1TSHRHSD17B10TP53MAPK1
SCHEMBL10160323 0.87 NOS3 (0.50) ALDH1A1TSHRHSD17B10TP53MAPK1
SCHEMBL27235773 0.82 ALDH1A1 (0.64) ALDH1A1TSHRHSD17B10TP53MAPK1
SCHEMBL995812 0.82 CA2 (0.50) ALDH1A1TSHRKDM4EGAANOS3
Lithium SCHEMBL31438907 0.80 ALDH1A1 (0.61) ALDH1A1TSHRHSD17B10TP53MAPK1
SCHEMBL25544161 0.76 MMP3 (0.56) ALDH1A1TSHRHSD17B10HPGDCYP2A6
SCHEMBL25543233 0.76 MMP3 (0.56) ALDH1A1TSHRHSD17B10HPGDCYP2A6
SCHEMBL9226615 0.76 ALDH1A1 (0.59) ALDH1A1TSHRHSD17B10MAPK1KDM4E
SCHEMBL19676602 0.76 SAE1 (0.51) ALDH1A1TSHRKDM4EGAAMAPT
SCHEMBL8849586 0.74 TSHR (0.59) ALDH1A1TSHRKDM4EMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8088932-B2 Pentaaryldiamine-containing bismaleimide compound and method of producing the compound INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2012-01-03 US disclosed
US-20100168442-A1 PENTAARYLDIAMINE-CONTAINING BISMALEIMIDE COMPOUND AND PRODUCING METHOD THEREOF INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2010-07-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100168442-A1 PENTAARYLDIAMINE-CONTAINING BISMALEIMIDE COMPOUND AND PRODUCING METHOD THEREOF ACMSD, ALDH7A1, ADSL ALDH1A1 177/4885TSHR 3872/4885HSD17B10 1135/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.