Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1S | Q13698 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HRH1 | P35367 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27619296 | 0.82 | ALDH1A1 (0.43) | CACNA1SMAPTKDM4EALDH1A1CHRM2 | |
| SCHEMBL27479625 | 0.77 | MTNR1A (0.40) | LMNAMAPTAADATGOT1KYAT1 | |
| SCHEMBL28752169 | 0.77 | AADAT (0.40) | ALDH1A1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL5629416 | 0.72 | CACNA1S (0.57) | CACNA1SLMNAMAPTHRH1KDM4E | |
| SCHEMBL11591800 | 0.71 | LMNA (0.47) | CACNA1SLMNAMAPTHRH1KDM4E | |
| SCHEMBL27600865 | 0.71 | TMEM97 (0.40) | LMNAKDM4EALDH1A1HTR1AADRA1A | |
| SCHEMBL27600849 | 0.71 | TMEM97 (0.40) | LMNAKDM4EALDH1A1HTR1AADRA1A | |
| SCHEMBL27409983 | 0.69 | GABRA1 (0.49) | LMNAMAPTHRH1SLC6A4CHRM2 | |
| SCHEMBL27537233 | 0.68 | BRPF1 (0.40) | CACNA1SLMNAMAPTHRH1KDM4E | |
| SCHEMBL10692391 | 0.65 | CACNA1S (0.57) | CACNA1SLMNAMAPTHRH1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100384852-C | Heterocyclic amide derivatives as inhibitors of glycogen phoshorylase | ASTRAZENECA AB (SE) | 2008-04-30 | — | — | CN | disclosed |
| CN-1653070-A | Heterocyclic amide derivatives as inhibitors of glycogen phoshorylase | ASTRAZENECA AB (SE) | 2005-08-10 | — | — | CN | disclosed |